| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4008514 | B | Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by IMAP assay | Homo sapiens | 24 | ALA4007409 | single protein format | Scientific Literature | |
| 2. | ALA4008516 | A | Intrinsic clearance in rat liver microsomes at 1 uM measured up to 30 mins in presence of NADPH by HPLC analysis | Rattus norvegicus | 19 | ALA4007409 | assay format | Scientific Literature | |
| 3. | ALA4008517 | A | Intrinsic clearance in human liver microsomes at 1 uM measured up to 30 mins in presence of NADPH by HPLC analysis | Homo sapiens | 14 | ALA4007409 | assay format | Scientific Literature | |
| 4. | ALA4008518 | B | Inhibition of PDE1B (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by IMAP assay | Homo sapiens | 1 | ALA4007409 | single protein format | Scientific Literature | |
| 5. | ALA4008519 | B | Inhibition of PDE3A (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by IMAP assay | Homo sapiens | 1 | ALA4007409 | single protein format | Scientific Literature | |
| 6. | ALA4008520 | B | Inhibition of PDE4D3 (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by IMAP assay | Homo sapiens | 1 | ALA4007409 | single protein format | Scientific Literature | |
| 7. | ALA4008521 | B | Inhibition of human full length N-terminal GST-tagged PDE11A4 expressed in Baculovirus infected Sf9 insect cells using cAMP as substrate | Homo sapiens | 1 | ALA4007409 | cell-based format | Scientific Literature | |
| 8. | ALA4008522 | B | Inhibition of PDE10A1 (unknown origin) using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by IMAP assay | Homo sapiens | 1 | ALA4007409 | single protein format | Scientific Literature | |
| 9. | ALA4008523 | B | Inhibition of PDE5A1 (unknown origin) expressed in Baculovirus infected Sf9 insect cells using fluorescently labeled cGMP as substrate by fluorescence polarization assay | Homo sapiens | 1 | ALA4007409 | cell-based format | Scientific Literature | |
| 10. | ALA4008524 | B | Inhibition of PDE6C (unknown origin) expressed in Baculovirus infected Sf9 insect cells using cGMP as substrate | Homo sapiens | 1 | ALA4007409 | cell-based format | Scientific Literature | |
| 11. | ALA4008525 | B | Inhibition of PDE7A (unknown origin) using fluorescently labeled cAMP as substrate | Homo sapiens | 1 | ALA4007409 | single protein format | Scientific Literature | |
| 12. | ALA4008526 | B | Inhibition of human full length N-terminal GST-tagged PDE8A1 expressed in Baculovirus infected Sf9 insect cells using cAMP as substrate | Homo sapiens | 1 | ALA4007409 | cell-based format | Scientific Literature | |
| 13. | ALA4008527 | B | Inhibition of human full length N-terminal GST-tagged PDE9A2 expressed in Baculovirus infected Sf9 insect cells using cGMP as substrate | Homo sapiens | 1 | ALA4007409 | cell-based format | Scientific Literature | |
| 14. | ALA4008528 | A | Oral bioavailability in Sprague-Dawley rat plasma at 1 mg/kg administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4007409 | organism-based format | Scientific Literature | |
| 15. | ALA4008529 | B | Inhibition of PDE2a in rat primary cortical neurons assessed as increase in Bay 41-8543-stimulated intracellular cGMP level preincubated for 30 mins followed by Bay 41-8543 addition measured after 30 mins by HTRF assay | Rattus norvegicus | 1 | ALA4007409 | cell-based format | Scientific Literature | |
| 16. | ALA4008530 | A | AUC (0 to infinity) in Sprague-Dawley rat plasma at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4007409 | organism-based format | Scientific Literature | |
| 17. | ALA4008531 | A | Elimination half life in Sprague-Dawley rat plasma at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4007409 | organism-based format | Scientific Literature | |
| 18. | ALA4008532 | A | Volume of distribution at steady state in Sprague-Dawley rat plasma at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4007409 | organism-based format | Scientific Literature | |
| 19. | ALA4008533 | A | Clearance in Sprague-Dawley rat plasma at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4007409 | organism-based format | Scientific Literature | |
| 20. | ALA4008534 | A | Clearance in Sprague-Dawley rat plasma at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis relative to hepatic blood flow | Rattus norvegicus | 1 | ALA4007409 | organism-based format | Scientific Literature |
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