| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4008461 | B | Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT-3 enzyme coupled assay | Mus musculus | 39 | assay format | Scientific Literature | ||
| 2. | ALA4008462 | F | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 56 hrs by MTT assay | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
| 3. | ALA4008463 | B | Inhibition of NAMPT in human Jurkat T cells assessed as reduction in NAD levels | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4008471 | A | Stability in human liver microsomes after 60 mins by LC-ESI-MS analysis | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 5. | ALA4008472 | A | Stability in Wistar Han rat liver microsomes after 60 mins by LC-ESI-MS analysis | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
| 6. | ALA4008473 | A | Drug metabolism in Wistar Han rat liver microsomes assessed as mixed function oxidase mediated compound cleavage by measuring compound remaining after 60 mins in presence of NADPH-regenerating system by LC-UV analysis | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
| 7. | ALA4008474 | A | Drug metabolism in human liver microsomes assessed as mixed function oxidase mediated compound cleavage by measuring compound remaining after 60 mins in presence of NADPH-regenerating system by LC-UV analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 8. | ALA4008477 | A | Drug metabolism in Wistar Han rat liver microsomes assessed as mixed function oxidase mediated compound degradation after 60 mins in presence of NADPH-regenerating system by LC-UV analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 9. | ALA4008478 | A | Drug metabolism in human liver microsomes assessed as mixed function oxidase mediated compound degradation after 60 mins in presence of NADPH-regenerating system by LC-UV analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4008479 | A | Drug metabolism in Wistar Han rat liver microsomes assessed as pyridine N-oxidation after 60 mins in presence of NADPH-regenerating system by LC-UV analysis | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 11. | ALA4008480 | A | Drug metabolism in human liver microsomes assessed as pyridine N-oxidation after 60 mins in presence of NADPH-regenerating system by LC-UV analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 12. | ALA4008492 | A | Half life in athymic Nu/Nu Harlan mouse at 10 mg/kg, iv administered as single dose up to 24 hrs by LC-ESI-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4008493 | A | AUC in athymic Nu/Nu Harlan mouse at 10 mg/kg, iv administered as single dose up to 24 hrs by LC-ESI-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4008494 | A | Clearance in athymic Nu/Nu Harlan mouse at 10 mg/kg, iv administered as single dose up to 24 hrs by LC-ESI-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4008495 | A | Volume of distribution in athymic Nu/Nu Harlan mouse at 10 mg/kg, iv administered as single dose up to 24 hrs by LC-ESI-MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4008496 | A | Drug metabolism in athymic Nu/Nu Harlan mouse blood assessed as N-oxide metabolite formation at 10 mg/kg, iv administered as single dose up to 24 hrs by LC-ESI-MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4008497 | P | Apparent aqueous solubility of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA4008498 | F | Cytotoxicity against human A2780 cells assessed as reduction in cell viability | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4008499 | F | Antitumor activity against human A2780 cells xenografted in athymic nu/nu Harlan mouse assessed as reduction in tumor growth at 10 mg/kg, ip bid administered for 8 consecutive days | Homo sapiens | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4008500 | T | Toxicity in athymic nu/nu Harlan mouse xenografted with human A2780 cells assessed as body weight loss at 10 mg/kg, ip bid administered for 8 consecutive days measured through out study | Mus musculus | 2 | organism-based format | Scientific Literature |
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