| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993207 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as compound concentration required to induce up to 3-fold leftward shift in glycine-induced increase in chloride ion flux after 4 mins by Schild plot analysis | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA3993208 | A | Intrinsic clearance in mouse liver microsomes up to 40 mins in presence of NADPH | Mus musculus | 23 | assay format | Scientific Literature | ||
| 3. | ALA3993209 | A | Passive apparent permeability in MDCK cells | Canis lupus familiaris | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA3993210 | A | Efflux ratio of passive apparent permeability in MDCK cells harboring human MDR1 | Canis lupus familiaris | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA3993211 | A | Efflux ratio of passive apparent permeability in MDCK cells harboring human BCRP | Canis lupus familiaris | 14 | cell-based format | Scientific Literature | ||
| 6. | ALA3993219 | B | Ex vivo positive allosteric modulation of glycine receptor in C57BL/6 mouse spinal cord assessed as potentiation of glycine-induced post synaptic current amplitude at 0.5 uM at holding potential of -60 mV after 10 mins in presence of sodium channel inhibitor TTX/AMPA/kainate receptor antagonist CNQX/GABAa receptor antagonist bicuculline/NMDA receptor antagonist APV by electrophysiology method relative to glycine alone | Mus musculus | 3 | assay format | Scientific Literature | ||
| 7. | ALA3993224 | U | Ratio of unbound Cmax in mouse brain to EC50 for glycine alpha3 receptor in mouse model of spared nerve injury-induced tactile allodynia at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3993229 | A | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3993230 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in chloride ion flux after 4 mins by membrane potential blue dye based FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA3993231 | B | Binding affinity to human glycine alpha3 receptor expressed in HEK293T cells by SPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA3993232 | F | Antiallodynic activity in mouse model of spared nerve injury-induced tactile allodynia assessed as tactile threshold at 20 mg/kg, po measured 60 mins post dose by Von Frey filament assay (Rvb = 0.82 +/- 0.19 g) | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4219619 | B | Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4219620 | B | Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4219621 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4219622 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4219623 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay relative to glycine | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4219928 | B | Positive allosteric modulation of human GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4219929 | B | Positive allosteric modulation of human GlyRalpha1beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4219930 | B | Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4219931 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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