| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4038063 | B | Inhibition of PDE4 in human whole blood PBMC assessed as reduction in LPS-induced TNFalpha production after 24 hrs by ELISA | Homo sapiens | 55 | ALA4033796 | assay format | Scientific Literature | |
| 2. | ALA4038064 | B | Inhibition of recombinant human PDE4B1 using [3H]-cAMP as substrate preincubated for 15 mins followed substrate addition measured after 60 mins by scintillation proximity assay | Homo sapiens | 55 | ALA4033796 | single protein format | Scientific Literature | |
| 3. | ALA4038065 | P | Apparent permeability of the compound by PAMPA assay | 3 | ALA4033796 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA4038066 | P | Thermodynamic solubility of the compound at 37 degC | 2 | ALA4033796 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4038068 | A | Cmax in Sprague-Dawley rat at 500 ug/kg, iv | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 6. | ALA4038069 | A | AUC in Sprague-Dawley rat at 500 ug/kg, iv | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 7. | ALA4038070 | A | Volume of distribution at steady state in Sprague-Dawley rat at 500 ug/kg, iv | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 8. | ALA4038071 | A | Half life in Sprague-Dawley rat at 500 ug/kg, iv | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 9. | ALA4038072 | A | Clearance in Sprague-Dawley rat at 500 ug/kg, iv | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 10. | ALA4038073 | A | Drug level in Sprague-Dawley rat lung at 1000 ug/kg, it administered as dry powder measured over 24 hrs post dose | Rattus norvegicus | 1 | ALA4033796 | tissue-based format | Scientific Literature | |
| 11. | ALA4038074 | A | Plasma concentration in Sprague-Dawley rat at 1000 ug/kg, it measured up to 1 hr post dose | Rattus norvegicus | 1 | ALA4033796 | cell-free format | Scientific Literature | |
| 12. | ALA4038075 | F | Antiinflammatory activity in Sprague-Dawley rat LPS-induced neutrophilia model assessed as inhibition of LPS-induced increase in netrophils in bronchoalveolar lavage at 1000 ug/kg, it administered single dose as microspray dosed 1 hr prior to nebulized LPS challenge measured after 4 hrs by flow cytometric analysis | Rattus norvegicus | 2 | ALA4033796 | organism-based format | Scientific Literature | |
| 13. | ALA4038076 | F | Antiinflammatory activity in Sprague-Dawley rat LPS-induced neutrophilia model assessed as inhibition of LPS-induced increase in netrophils in bronchoalveolar lavage at 100 to 3000 ug/kg, it administered as single dose via dry powder insufflator dosed 1 to 18 hrs prior to nebulized LPS challenge measured after 4 hrs by flow cytometric analysis | Rattus norvegicus | 1 | ALA4033796 | organism-based format | Scientific Literature | |
| 14. | ALA4038077 | A | Pro-inflammatory activity in Sprague-Dawley rat assessed as increase in neutrophils in bronchoalveolar lavage at 1000 ug/kg, it administered as single dose via dry powder insufflator after 18 hrs post dose by flow cytometric analysis relative to basal level | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 15. | ALA4038078 | A | Pro-inflammatory activity in Sprague-Dawley rat assessed as increase in neutrophils in bronchoalveolar lavage at 3000 ug/kg, it administered as single dose via dry powder insufflator after 18 hrs post dose by flow cytometric analysis relative to basal level | Rattus norvegicus | 1 | ALA4033796 | assay format | Scientific Literature | |
| 16. | ALA4038079 | T | Toxicity in ferret assessed as emesis at 30 ug/kg, it administered as dry powder co-mixtured with lactose after 1 hr post dose | Mustela putorius furo | 1 | ALA4033796 | assay format | Scientific Literature | |
| 17. | ALA4038080 | T | Toxicity in it dosed ferret assessed as emesis administered as dry powder co-mixtured with lactose after 1 hr post dose | Mustela putorius furo | 1 | ALA4033796 | organism-based format | Scientific Literature | |
| 18. | ALA4038084 | A | Drug level in Sprague-Dawley rat lung at 1000 ug/kg, it administered as dry powder measured up to 6 hrs post dose | Rattus norvegicus | 1 | ALA4033796 | tissue-based format | Scientific Literature | |
| 19. | ALA4038085 | A | Drug level in Sprague-Dawley rat lung at 1000 ug/kg, it administered as dry powder measured at 6 hrs post dose | Rattus norvegicus | 1 | ALA4033796 | tissue-based format | Scientific Literature | |
| 20. | ALA4038086 | A | Drug level in Sprague-Dawley rat lung at 1000 ug/kg, it administered as dry powder measured up to 18 hrs post dose | Rattus norvegicus | 1 | ALA4033796 | tissue-based format | Scientific Literature |
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