| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4017851 | B | Inhibition of RND efflux pump in Pseudomonas aeruginosa PAO1 assessed as potentiation of minocycline-induced antibacterial activity by measuring minocycline MIC at 8 ug/ml after 18 to 24 hrs by microbroth dilution assay (Rvb = 8 ug/ml) | Pseudomonas aeruginosa PAO1 | 11 | assay format | Scientific Literature | ||
| 2. | ALA4017852 | F | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 18 to 24 hrs by microbroth dilution assay | Pseudomonas aeruginosa | 12 | assay format | Scientific Literature | ||
| 3. | ALA4017853 | B | Inhibition of RND efflux pump in Pseudomonas aeruginosa PAO1 assessed as potentiation of minocycline-induced antibacterial activity at 8 ug/ml after 18 to 24 hrs by checker board assay | Pseudomonas aeruginosa PAO1 | 15 | assay format | Scientific Literature | ||
| 4. | ALA4017854 | B | Inhibition of RND efflux pump in Pseudomonas aeruginosa PAO1 assessed as potentiation of minocycline-induced antibacterial activity by measuring fold reduction in minocycline MIC at 8 ug/ml after 18 to 24 hrs by microbroth dilution assay relative to minocycline alone | Pseudomonas aeruginosa PAO1 | 3 | assay format | Scientific Literature | ||
| 5. | ALA4017886 | A | Toxicity in Galleria mellonella assessed as death at 100 mg/kg after 24 hrs relative to control | Galleria mellonella | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA4017904 | B | Inhibition of RND efflux pump in Klebsiella pneumoniae isolate 116381 assessed as potentiation of minocycline-induced antibacterial activity by measuring minocycline MIC at 8 ug/ml after 18 to 24 hrs by microbroth dilution assay (Rvb = 128 ug/ml) | Klebsiella pneumoniae | 6 | assay format | Scientific Literature | ||
| 7. | ALA4017905 | B | Inhibition of RND efflux pump in Enterobacter cloacae isolate 117029 assessed as potentiation of minocycline-induced antibacterial activity by measuring minocycline MIC at 8 ug/ml after 18 to 24 hrs by microbroth dilution assay (Rvb = 128 to 256 ug/ml) | Enterobacter cloacae | 6 | assay format | Scientific Literature | ||
| 8. | ALA4017906 | B | Inhibition of RND efflux pump in Klebsiella pneumoniae isolate 116381 assessed as potentiation of minocycline-induced antibacterial activity at 8 ug/ml after 18 to 24 hrs by microbroth dilution assay | Klebsiella pneumoniae | 6 | assay format | Scientific Literature | ||
| 9. | ALA4017907 | B | Inhibition of RND efflux pump in Enterobacter cloacae isolate 117029 assessed as potentiation of minocycline-induced antibacterial activity at 8 ug/ml after 18 to 24 hrs by microbroth dilution assay | Enterobacter cloacae | 6 | assay format | Scientific Literature | ||
| 10. | ALA4017908 | F | Antibacterial activity against Klebsiella pneumoniae isolate 116381 after 18 to 24 hrs by microbroth dilution assay | Klebsiella pneumoniae | 6 | assay format | Scientific Literature | ||
| 11. | ALA4017909 | F | Antibacterial activity against Enterobacter cloacae isolate 117029 after 18 to 24 hrs by microbroth dilution assay | Enterobacter cloacae | 6 | assay format | Scientific Literature | ||
| 12. | ALA4017929 | B | Inhibition of RND efflux pump in Pseudomonas aeruginosa PAO1 assessed as increase in tetracycline uptake at 13.6 ug/ml measured at 1 min interval for 30 mins by fluorescence assay | Pseudomonas aeruginosa PAO1 | 1 | assay format | Scientific Literature | ||
| 13. | ALA4017931 | B | Inhibition of RND efflux pump in Pseudomonas aeruginosa PAO1 assessed as potentiation of minocycline-induced antibacterial activity by measuring ratio of minocycline MIC after 25 serial passages to minocycline MIC at sub-MIC after 18 to 24 hrs by microbroth dilution assay | Pseudomonas aeruginosa PAO1 | 3 | assay format | Scientific Literature |
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