| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4018539 | B | Binding affinity to N-terminal NT-647-NHS labeled NM23-H2 (unknown origin) after 30 mins by MST analysis | Homo sapiens | 47 | single protein format | Scientific Literature | ||
| 2. | ALA4018549 | B | Binding affinity to Htg21 telomeric G-quadruplex DNA (unknown origin) at 40 uM after 30 mins by SPR analysis | Not specified | 47 | assay format | Scientific Literature | ||
| 3. | ALA4018550 | B | Binding affinity to biotin-labeled 18-mer duplex DNA hairpin (unknown origin) at 40 uM after 30 mins by SPR analysis | Not specified | 47 | assay format | Scientific Literature | ||
| 4. | ALA4018616 | B | Binding affinity to NM23-H2 (unknown origin) up to 40 uM by SPR analysis | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 5. | ALA4320939 | B | Inhibition of ATP hydrolysis activity of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) at 1 to 10 uM | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4320940 | B | Binding affinity to DNA (unknown origin) up to 2 molar ratio by ITC | Not specified | 1 | nucleic acid format | Scientific Literature | ||
| 7. | ALA4320941 | B | Inhibition of His-tagged BLM E1143A mutant (unknown origin) binding to DNA assessed as effect on unbound DNA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4320942 | B | Inhibition of His-tagged BLM I1168A mutant (unknown origin) binding to DNA assessed as effect on unbound DNA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4320943 | B | Inhibition of His-tagged BLM M1111A mutant (unknown origin) binding to DNA assessed as effect on unbound DNA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4320944 | B | Inhibition of His-tagged BLM H996A mutant (unknown origin) binding to DNA assessed as effect on unbound DNA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4320945 | B | Inhibition of His-tagged BLM Y995A mutant (unknown origin) binding to DNA assessed as effect on unbound DNA | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4320946 | F | Chemosensitization activity in human HCT116 cells assessed as RI-I-induced antiproliferative activity at 1.25 uM in presence of RI-I and BLM siRNA after 24 hrs by MTT assay (Rvb = 15.4%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4320947 | F | Effect on RAD51 protein expression in in human HCT116 cells at 1 to 2 after 24 hrs | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4320948 | B | Inhibition of BLM in human HCT116 cells assessed as induction of RAD51 recruitment to DSB sites on chromosomes at 0.5 to 1 uM after 48 hrs by ChIP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4320949 | B | Inhibition of BLM in human HCT116 cells assessed as induction of HRR up-regulation at 1 uM after 24 hrs by GFP-based flow cytometry relative to untreated control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4320950 | B | Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity at 50 uM using 5'-biotin labeled forked-DNA as substrate after 1 hr by PAGE analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 17. | ALA4320951 | B | Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity at 10 uM using 5'-biotin labeled forked-DNA as substrate after 1 hr by PAGE analysis | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 18. | ALA4320952 | B | Inhibition of BLM recruitment to DSB sites on chromosomes in human HCT116 cells at 0.5 to 1 uM after 48 hrs by ChIP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4320953 | B | Inhibition of 5'-biotin labeled duplex forked-DNA binding to BLM (unknown origin) assessed as increase in unbound DNA levels at 0.5 to 1 uM after 1 hr by filter-binding assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4320954 | B | Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity at 1 uM using 5'-biotin labeled forked-DNA as substrate after 1 hr by PAGE analysis | Homo sapiens | 5 | assay format | Scientific Literature |
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