# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4008552 | U | Critical micellar concentration of the compound measured after 1 hr by pyrene fluorescence excitation spectral analysis | 4 | assay format | Scientific Literature | |||
2. | ALA4008553 | P | Solubility of the compound in presence of beta-cyclodextrin | 4 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4008554 | B | Competitive inhibition of bovine liver beta-glucosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside by Lineweaver-Burk Plot analysis | Bos taurus | 4 | assay format | Scientific Literature | ||
4. | ALA4008555 | B | Inhibition of human GCase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside at pH 5 by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
5. | ALA4008556 | B | Inhibition of human GCase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside at pH 7 by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
6. | ALA4008565 | B | Inhibition of human lysosomal alpha-glucosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
7. | ALA4008566 | B | Inhibition of human lysosomal alpha-galactosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-galactopyranoside up to 200 uM by luminescence spectrophotometry | Homo sapiens | 4 | assay format | Scientific Literature | ||
8. | ALA4008567 | B | Inhibition of human lysosomal beta-galactosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl beta-D-galactopyranoside up to 200 uM by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
9. | ALA4008568 | B | Inhibition of human lysosomal alpha-mannosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside up to 200 uM by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
10. | ALA4008569 | B | Inhibition of human lysosomal beta-mannosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside up to 200 uM by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
11. | ALA4008570 | B | Inhibition of human lysosomal beta-hexosaminidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide up to 200 uM by luminescence spectrophotometry | Homo sapiens | 4 | assay format | Scientific Literature | ||
12. | ALA4008571 | B | Effect on GCase activity in fibroblasts derived from gaucher disease patient up to 100 uM using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 96 hrs by luminescence spectrophotometry | Homo sapiens | 2 | single protein format | Scientific Literature | ||
13. | ALA4008572 | A | Cytotoxicity against human fibroblasts assessed as cell viability up to 100 uM after 24 hrs by lactate dehydrogenase assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4008577 | B | Chaperone activity assessed as enhancement of GCase V230G/R296X mutant enzyme in fibroblasts derived from gaucher disease patient at 20 uM using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 96 hrs by luminescence spectrophotometry | Homo sapiens | 2 | assay format | Scientific Literature | ||
15. | ALA4008579 | B | Competitive inhibition of bovine liver beta-glucosidase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside in presence of beta-cyclodextrin by Lineweaver-Burk Plot analysis | Bos taurus | 4 | assay format | Scientific Literature | ||
16. | ALA4008580 | B | Inhibition of human GCase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside at pH 5 in presence of beta-cyclodextrin by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
17. | ALA4008581 | B | Inhibition of human GCase assessed as formation of 4-methylumbelliferone from 4-methylumbelliferyl alpha-D-glucopyranoside at pH 7 in presence of beta-cyclodextrin by luminescence spectrophotometry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
18. | ALA4008583 | B | Inhibition of green coffee bean alpha-galactosidase at 2 mM using beta-D-glycopyranoside after 10 to 30 mins in presence of beta-cyclodextrin by spectrophotometry | Coffea arabica | 4 | single protein format | Scientific Literature | ||
19. | ALA4008584 | B | Inhibition of jack bean alpha-mannosidase at 2mM using beta-D-glycopyranoside after 10 to 30 mins in presence of beta-cyclodextrin by spectrophotometry | Canavalia ensiformis | 4 | single protein format | Scientific Literature | ||
20. | ALA4008585 | B | Inhibition of almond beta-glucosidase at 2 mM using beta-D-glycopyranoside after 10 to 30 mins in presence of beta-cyclodextrin by spectrophotometry | Prunus dulcis | 4 | assay format | Scientific Literature |