# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4059390 | P | Effective permeability of compound at pH 7.4 after 16 hrs by PAMPA | 8 | ALA4052832 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4059391 | P | Octanol-water partition coefficient, log D of compound at pH 7.4 at 10 uM after 2 hrs by LC-MS based shake flask analysis | 8 | ALA4052832 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4059398 | B | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 22 | ALA4052832 | assay format | Scientific Literature | |
4. | ALA4059399 | B | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 22 | ALA4052832 | assay format | Scientific Literature | |
5. | ALA4059400 | B | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | Homo sapiens | 22 | ALA4052832 | assay format | Scientific Literature | |
6. | ALA4261234 | B | Inhibition of human His6-tagged NEU1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 46 | ALA4257588 | cell-based format | Scientific Literature | |
7. | ALA4261235 | B | Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 46 | ALA4257588 | assay format | Scientific Literature | |
8. | ALA4261236 | B | Inhibition of N-terminal MBP-fused human NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 46 | ALA4257588 | assay format | Scientific Literature | |
9. | ALA4261237 | B | Inhibition of MBP-fused human NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 46 | ALA4257588 | assay format | Scientific Literature | |
10. | ALA4261239 | B | Non-competitive inhibition of human His6-tagged NEU1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated with substrate for 15 mins and measured every min for 30 mins by Lineweaver-Burk plot analysis | Homo sapiens | 1 | ALA4257588 | cell-based format | Scientific Literature | |
11. | ALA4261240 | B | Competitive inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated with substrate for 15 mins and measured every min for 30 mins by Lineweaver-Burk plot analysis | Homo sapiens | 5 | ALA4257588 | assay format | Scientific Literature | |
12. | ALA4418859 | F | Reduction in size of fatty streaks in aortic root of normal diet fed 16 week old ApoE KO mouse at 30 mg/kg, ip treated for 2 weeks (once every 2 days for first week and then every day for second week) by Oil Red O staining based assay relative to control | Mus musculus | 2 | ALA4418500 | organism-based format | Patent Bioactivity Data | |
13. | ALA4418860 | F | Reduction in size of fatty streaks in aortic root of normal diet fed 12 week old ApoE KO mouse at 30 mg/kg, ip treated for 4 weeks (once every 2 days for first 2 weeks and then every day for third and the fourth weeks) by Oil Red O staining based assay relative to control | Mus musculus | 2 | ALA4418500 | organism-based format | Patent Bioactivity Data | |
14. | ALA4418863 | B | Inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 71 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
15. | ALA4418864 | B | Inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 67 | ALA4418500 | assay format | Patent Bioactivity Data | |
16. | ALA4418865 | B | Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 67 | ALA4418500 | assay format | Patent Bioactivity Data | |
17. | ALA4418866 | B | Inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 67 | ALA4418500 | assay format | Patent Bioactivity Data | |
18. | ALA4418875 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli to IC50 for inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells | Homo sapiens | 29 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
19. | ALA4418876 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli to IC50 for inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells | Homo sapiens | 29 | ALA4418500 | cell-based format | Patent Bioactivity Data | |
20. | ALA4418877 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal GST tagged human neuraminidase-4 expressed in Escherichia coli to IC50 for inhibition of His6-tagged human neuraminidase-1 expressed in HEK293 cells | Homo sapiens | 28 | ALA4418500 | cell-based format | Patent Bioactivity Data |