| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4047062 | B | Inhibition of PDE4B isolated from human U937 cells using [3H]-cAMP incubated for 30 mins | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 2. | ALA4047063 | A | Inhibition of PDE4D isolated from human U937 cells using [3H]-cAMP incubated for 30 mins | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 3. | ALA4047064 | F | Inhibition of LPS-induced TNFalpha production in human PBMC pre-incubated for 30 mins before LPS stimulation for 18 hrs by TR-FRET assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 4. | ALA4047065 | F | Potency index, ratio of IC50 for rolipram to IC50 for test compound for inhibition of LPS-induced TNFalpha production in human PBMC pre-incubated for 30 mins before LPS stimulation for 18 hrs by TR-FRET assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4047066 | A | Inhibition of human PDE1A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4047067 | A | Inhibition of human PDE2A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4047068 | A | Inhibition of human PDE3B at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4047069 | B | Inhibition of human PDE4B at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4047070 | A | Inhibition of human PDE5A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4047071 | A | Inhibition of human PDE6C at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4047072 | A | Inhibition of human PDE7A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4047073 | A | Inhibition of human PDE8A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4047074 | A | Inhibition of human PDE9A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4047075 | A | Inhibition of human PDE10A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4047076 | A | Inhibition of human PDE11A at 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4047077 | F | Inhibition of LPS-induced TNFalpha production in Swiss Albino mouse model of sepsis at 10 mg/kg, po pre-treated 30 mins before LPS challenge and measured 90 mins post LPS injection by ELISA method relative to untreated control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4047078 | F | Inhibition of LPS-induced neutropenia in Sprague-Dawley rat model of asthma assessed as reduction in neutrophils in BAL fluid at 10 mg/kg, po pre-treated 30 mins before LPS challenge and measured 6 hrs after LPS injection relative to untreated control | Rattus norvegicus | 3 | organism-based format | Scientific Literature |
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