# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4029482 | B | Inhibition of full length N-terminal GST/His6-tagged human CDK8 (M1 to Y463 residues)/N-terminal His6-tagged Cyc C (M1 to S283 residues) expressed in Sf9 insect cells at 1 uM using RBER-IRStide as substrate by filter binding assay | Homo sapiens | 1 | ALA4028808 | cell-based format | Scientific Literature | |
2. | ALA4220216 | B | Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric method | Homo sapiens | 2 | ALA4219051 | protein complex format | Scientific Literature | |
3. | ALA4220240 | B | Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric method | Homo sapiens | 2 | ALA4219051 | protein complex format | Scientific Literature | |
4. | ALA4220241 | B | Inhibition of MAP4K2 (unknown origin) at 2 uM relative to control | Homo sapiens | 1 | ALA4219051 | single protein format | Scientific Literature | |
5. | ALA4220242 | B | Inhibition of YSK4 (unknown origin) at 2 uM relative to control | Homo sapiens | 1 | ALA4219051 | single protein format | Scientific Literature | |
6. | ALA4742525 | F | Induction of rescue of anemia in RPS19-deficient mouse model for DBA assessed as improvement in erythrocytes production at 10 mg/kg, po dosed every 12 hrs for 5 times and measured 48 hrs after last dose | Mus musculus | 12 | ALA4742393 | organism-based format | Patent Bioactivity Data | |
7. | ALA4742526 | F | Rescue of proliferation of CD34+ erythroid progenitor cells isolated from DBA patient with RPS35a mutation at 200 nM measured at day 14 of culture | Homo sapiens | 3 | ALA4742393 | tissue-based format | Patent Bioactivity Data | |
8. | ALA4742527 | F | Rescue of proliferation of CD34+ erythroid progenitor cells isolated from DBA patient with RPS26 mutation at 200 nM measured at day 14 of culture | Homo sapiens | 3 | ALA4742393 | tissue-based format | Patent Bioactivity Data | |
9. | ALA4742528 | F | Rescue of proliferation of CD34+ erythroid progenitor cells isolated from DBA patient with RPS19 mutation at 200 nM measured at day 14 of culture | Homo sapiens | 3 | ALA4742393 | tissue-based format | Patent Bioactivity Data | |
10. | ALA4742529 | F | Increase in erythroid maturation of erythroid progenitor cells isolated from DBA patient assessed as increase in CD71 and CD235a positive cells level measured at day 8 of culture by flow cytometry | Homo sapiens | 3 | ALA4742393 | tissue-based format | Patent Bioactivity Data | |
11. | ALA4742530 | B | Inhibition of CDK8/CDK19 assessed as rescue of proliferation of RPS19-deficient mouse erythroid progenitor cells by cell-based phenotypic screening assay | Mus musculus | 12 | ALA4742393 | tissue-based format | Patent Bioactivity Data | |
12. | ALA4742531 | B | Inhibition of CDK8/CDK19 assessed as rescue of proliferation of RPS19-deficient erythroid progenitor cells isolated from mouse model of DBA by cell-based phenotypic screening assay relative to control | Mus musculus | 12 | ALA4742393 | tissue-based format | Patent Bioactivity Data | |
13. | ALA4805237 | B | Inhibition of human CDK19 by DiscoverX assay | Homo sapiens | 2 | ALA4804282 | single protein format | Patent Bioactivity Data | |
14. | ALA4805238 | B | Inhibition of human CDK8 by DiscoverX assay | Homo sapiens | 2 | ALA4804282 | single protein format | Patent Bioactivity Data | |
15. | ALA4805239 | B | Inhibition of human HASPIN by DiscoverX assay | Homo sapiens | 2 | ALA4804282 | single protein format | Patent Bioactivity Data | |
16. | ALA4805240 | B | Inhibition of human MAP4K2 by DiscoverX assay | Homo sapiens | 2 | ALA4804282 | single protein format | Patent Bioactivity Data | |
17. | ALA4805241 | B | Inhibition of human MYO3B by DiscoverX assay | Homo sapiens | 2 | ALA4804282 | single protein format | Patent Bioactivity Data | |
18. | ALA4805245 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of MYC expression by QPCR assay | Homo sapiens | 2 | ALA4804282 | tissue-based format | Patent Bioactivity Data | |
19. | ALA4805246 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of CXCL1 expression by QPCR assay | Homo sapiens | 2 | ALA4804282 | tissue-based format | Patent Bioactivity Data | |
20. | ALA4805247 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of IL-8 expression by QPCR assay | Homo sapiens | 2 | ALA4804282 | tissue-based format | Patent Bioactivity Data |