# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4010335 | B | Inhibition of human DcpS assessed as increase in SMN2 promoter activity | Homo sapiens | 29 | single protein format | Scientific Literature | ||
2. | ALA4010336 | A | Inhibition of DHFR (unknown origin) | Homo sapiens | 17 | single protein format | Scientific Literature | ||
3. | ALA4010337 | A | Apparent intrinsic clearance in human liver microsomes at 1 uM | Homo sapiens | 3 | assay format | Scientific Literature | ||
4. | ALA4010338 | A | Apparent passive permeability across apical to basolateral side in RRCK2 cells at 2 uM | Canis lupus familiaris | 3 | cell-based format | Scientific Literature | ||
5. | ALA4010339 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side of MDCK cells expressing MDR1 | Canis lupus familiaris | 3 | cell-based format | Scientific Literature | ||
6. | ALA4010340 | P | Kinetic solubility of the compound at pH 6.5 | 3 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4010341 | P | Lipophilicity, log D of the compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4010342 | A | Unbound fraction in FVB/N mouse plasma at 30 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
9. | ALA4010343 | A | Fraction unbound in FVB/N mouse brain at 30 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA4010344 | A | Fraction unbound in FVB/N mouse CSF at 30 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA4010345 | F | Neuroprotective activity in FVB/N mouse model of 2B/-spinal muscular atrophy assessed as reduction in disease phenotypic changes at 30 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
12. | ALA4010346 | A | Stability in human liver microsomes at 1 uM | Homo sapiens | 3 | assay format | Scientific Literature | ||
13. | ALA4010347 | A | Ratio of fraction unbound in FVB/N mouse plasma to fraction unbound in FVB/N mouse brain | Mus musculus | 1 | assay format | Scientific Literature |