# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4024931 | Binding | Inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as substrate pretreated for 60 mins followed by substrate addition after 1 hr by ADP-Glo luminescence assay | Homo sapiens | 49 | ALA4024706 | cell-based format | Scientific Literature | |
2. | ALA4024932 | Binding | Inhibition of full length recombinant human N-terminal GST-tagged BMX expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as substrate pretreated for 60 mins followed by substrate addition after 1 hr by ADP-Glo luminescence assay | Homo sapiens | 8 | ALA4024706 | cell-based format | Scientific Literature | |
3. | ALA4024933 | Binding | Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as substrate pretreated for 60 mins followed by substrate addition after 1 hr by ADP-Glo luminescence assay | Homo sapiens | 8 | ALA4024706 | cell-based format | Scientific Literature | |
4. | ALA4024934 | Binding | Inhibition of recombinant human N-terminal GST-tagged wild-type EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as substrate pretreated for 60 mins followed by substrate addition after 1 hr by ADP-Glo luminescence assay | Homo sapiens | 8 | ALA4024706 | cell-based format | Scientific Literature | |
5. | ALA4024935 | Binding | Irreversible inhibition of recombinant full length wild-type 3'-FLAG-tagged BTK (unknown origin) expressed in HEK293T cells assessed as reduction in Y223 phosphorylation measured after 4 hrs by Western blot method | Homo sapiens | 2 | ALA4024706 | cell-based format | Scientific Literature | |
6. | ALA4024936 | Binding | Irreversible inhibition of recombinant full length 3'-FLAG-tagged BTK C481S mutant (unknown origin) expressed in HEK293T cells assessed as reduction in Y223 phosphorylation measured after 4 hrs by Western blot method | Homo sapiens | 2 | ALA4024706 | cell-based format | Scientific Literature | |
7. | ALA4024937 | Binding | Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells assessed as inactivation rate using poly (Glu,Tyr)4:1 as substrate pretreated for 2 to 60 mins followed by substrate addition after 1 hr by ADP-Glo luminescence assay | Homo sapiens | 8 | ALA4024706 | cell-based format | Scientific Literature | |
8. | ALA4024938 | Binding | Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as substrate pretreated for 2 to 60 mins followed by substrate addition after 1 hr by ADP-Glo luminescence assay | Homo sapiens | 8 | ALA4024706 | cell-based format | Scientific Literature | |
9. | ALA4024939 | Binding | Ratio of Kinact to Ki for full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells | Homo sapiens | 8 | ALA4024706 | cell-based format | Scientific Literature | |
10. | ALA4024940 | Functional | Growth inhibition of human SU-DHL-2 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
11. | ALA4024941 | Functional | Growth inhibition of human MV411 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
12. | ALA4024942 | Functional | Growth inhibition of human U2932 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
13. | ALA4024943 | Functional | Growth inhibition of human Ramos cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
14. | ALA4024944 | Functional | Growth inhibition of human OCI-AML3 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
15. | ALA4024945 | Functional | Growth inhibition of human Pfeiffer cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
16. | ALA4024946 | Functional | Growth inhibition of human U937 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
17. | ALA4024947 | Functional | Growth inhibition of human NB4 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
18. | ALA4024948 | Functional | Growth inhibition of human SKM1 cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
19. | ALA4024949 | Functional | Growth inhibition of human M07e cells | Homo sapiens | 6 | ALA4024706 | cell-based format | Scientific Literature | |
20. | ALA4024950 | ADME | Cytotoxicity against PBMC (unknwon origin) | Not specified | 5 | ALA4024706 | cell-based format | Scientific Literature |