# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4033519 | F | Ex vivo receptor occupancy at P2X7 in Sprague-Dawley rat assessed as brain drug level causing 50% reduction in [3H]A-804598 receptor labeling in hippocampus at 10 mg/kg, po measured after 2 hrs by radioligand binding autoradiography method | Rattus norvegicus | 4 | ALA4028916 | organism-based format | Scientific Literature | |
2. | ALA4033520 | F | Ex vivo receptor occupancy at P2X7 in Sprague-Dawley rat assessed as plasma drug level causing 50% reduction in [3H]A-804598 receptor labeling in hippocampus at 10 mg/kg, po measured after 2 hrs by radioligand binding autoradiography method | Rattus norvegicus | 4 | ALA4028916 | organism-based format | Scientific Literature | |
3. | ALA4427221 | B | Antagonist activity at human recombinant P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins measured after 180 seconds by calcium-4 dye based FLIPR assay | Homo sapiens | 11 | ALA4425156 | cell-based format | Scientific Literature | |
4. | ALA4427222 | B | Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization incubated for 30 mins measured after 180 seconds by calcium-4 dye based FLIPR assay | Rattus norvegicus | 11 | ALA4425156 | cell-based format | Scientific Literature | |
5. | ALA4427223 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in human Caco2 cells at 10 uM after 40 to 60 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4425156 | cell-based format | Scientific Literature | |
6. | ALA4427224 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 1 | ALA4425156 | organism-based format | Scientific Literature | |
7. | ALA4427225 | A | Ratio of drug level in brain to plasma in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA4425156 | organism-based format | Scientific Literature | |
8. | ALA4427226 | F | Ex vivo receptor occupancy at P2X7 receptor in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA4425156 | organism-based format | Scientific Literature |