| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993036 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM after 1 hr by LC-MS/MS analysis | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA3993037 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 10 uM after 1 hr by LC-MS/MS analysis | Mus musculus | 23 | assay format | Scientific Literature | ||
| 3. | ALA3993038 | A | Half life in human liver microsomes at 10 uM by LC-MS/MS analysis | Homo sapiens | 22 | assay format | Scientific Literature | ||
| 4. | ALA3993039 | A | Half life in mouse liver microsomes at 10 uM by LC-MS/MS analysis | Mus musculus | 23 | assay format | Scientific Literature | ||
| 5. | ALA3993041 | A | Cytotoxicity in HEK293 cells after 48 hrs by Cell-titer Glo reagent based assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 6. | ALA3993042 | A | Cytotoxicity in human HepG2 cells after 48 hrs by Cell-titer Glo reagent based assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 7. | ALA3993043 | A | Cytotoxicity in human BEAS2B cells after 48 hrs by Cell-titer Glo reagent based assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 8. | ALA3993044 | T | Neurotoxicity in Swiss Webster mouse assessed as induction of senorimotor impairment at 40 mg/kg, ip administered 10 mins prior to testing and measured for 3 mins at 10 to 60 mins after drug administration by rotarod method | Mus musculus | 9 | organism-based format | Scientific Literature | ||
| 9. | ALA3993045 | F | Inhibition of substance P-induced smooth muscle contractile force in guinea pig tracheal rings at 16 uM after 1 hr | Cavia porcellus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3993046 | A | Activity at GABAA alpha1beta3gamma2 receptor (unknown origin) expressed in HEK293T cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 1 uM by patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3993047 | B | Activity at GABAA alpha4beta3gamma2 receptor (unknown origin) expressed in HEK293T cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 1 uM by patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3993048 | F | Antiasthamatic effect in BALB/c mouse model of ovalbumin-induced asthma assessed as inhibition of airway hyperresponsiveness at 40 mg/kg, ip administered 40 mins as single dose prior to measurement | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3993049 | F | Antiasthamatic effect in BALB/c mouse model of ovalbumin-induced asthma assessed as inhibition of airway hyperresponsiveness at 40 mg/kg, ip bid for 5 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3993050 | A | Tmax in mouse blood at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3993051 | A | Cmax in mouse blood at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3993052 | A | Half life in mouse blood at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3993053 | A | AUC (0 to t) in mouse blood at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3993054 | A | Tmax in mouse brain at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3993055 | A | Cmax in mouse brain at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3993056 | A | Half life in mouse brain at 5 mg/kg, ip by LC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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