Drug metabolism in cynomolgus monkey liver microsomes assessed as 5-(Hydroxymethyl)-7-(3-(hydroxymethyl)-1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)-2-methylimidazo-[5,1-f ][1,2,4]triazin-4(3H)-one formation at 20 uM after 1.2 hrs by UHPLC-UV-HRMS method
Drug metabolism in cynomolgus monkey liver microsomes assessed as 7-(1,3-Dimethyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)-5-(hydroxymethyl)-2-methylimidazo[5,1-f ][1,2,4]triazin-4(3H)-one formation at 20 uM after 1.2 hrs by UHPLC-UV-HRMS method
Drug metabolism in cynomolgus monkey liver microsomes assessed as 7-(3-(Hydroxymethyl)-1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-4-yl)-2,5-dimethylimidazo[5,1-f ][1,2,4]triazin-4(3H)-one formation at 20 uM after 1.2 hrs by UHPLC-UV-HRMS method
Drug metabolism in cynomolgus monkey liver microsomes assessed as 4-(2,5-Dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f ][1,2,4]triazin-7-yl)-1-methyl-5-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazole-3-carbaldehyde formation at 20 uM after 1.2 hrs by UHPLC-UV-HRMS method