| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4039407 | T | Toxicity in scid mouse xenografted with human U2932 cells assessed as survival at 5 mg/kg, ip administered for 5 consecutive days cotreated with NSC-59276 and CPA | Mus musculus | 1 | ALA4038303 | organism-based format | Scientific Literature | |
| 2. | ALA4039408 | F | Down regulation of BLC2 mRNA level in human HT cells up to 3 uM after 24 hrs by qPCR method | Homo sapiens | 2 | ALA4038303 | cell-based format | Scientific Literature | |
| 3. | ALA4039409 | B | Binding affinity to c-myc G-quadruplex DNA in BCL2 and MYC translocation-positive human VAL cells assessed as downregulation of MYC protein levels up to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 4. | ALA4039410 | B | Binding affinity to c-myc G-quadruplex DNA in human HT cells assessed as downregulation of MYC protein levels up to 3 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4038303 | cell-based format | Scientific Literature | |
| 5. | ALA4039411 | B | Binding affinity to c-myc G-quadruplex DNA in MYC translocation-positive and BCL2 amplification-positive human U2932 cells assessed as downregulation of MYC mRNA levels up to 3 uM after 24 hrs by qPCR method relative to control | Homo sapiens | 2 | ALA4038303 | assay format | Scientific Literature | |
| 6. | ALA4039412 | B | Binding affinity to c-myc G-quadruplex DNA in BCL2 translocation-positive human SUDHL4 cells assessed as downregulation of MYC mRNA levels up to 3 uM after 24 hrs by qPCR method relative to control | Homo sapiens | 2 | ALA4038303 | assay format | Scientific Literature | |
| 7. | ALA4039413 | B | Binding affinity to BLC2 G-quadruplex DNA in BCL2 translocation-positive human SUDHL4 cells assessed as downregulation of BLC2 mRNA levels at 3 uM after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 8. | ALA4039414 | B | Binding affinity to BLC2 i-motif promoter DNA in BCL2 and MYC translocation-positive human VAL cells assessed as downregulation of BLC2 mRNA levels up to 3 uM after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 9. | ALA4039415 | B | Binding affinity to BLC2 i-motif promoter DNA in MYC translocation-positive and BCL2 amplification-positive human U2932 cells assessed as downregulation of BLC2 mRNA levels up to 3 uM after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 10. | ALA4039416 | B | Binding affinity to c-myc G-quadruplex DNA in BCL2 translocation-positive human SUDHL4 cells assessed as downregulation of MYC mRNA levels after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 11. | ALA4039417 | B | Binding affinity to c-myc G-quadruplex DNA in MYC translocation-positive and BCL2 amplification-positive human U2932 cells assessed as downregulation of MYC mRNA levels after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 12. | ALA4039418 | B | Binding affinity to c-myc G-quadruplex DNA in BCL2 and MYC translocation-positive human VAL cells assessed as downregulation of MYC mRNA levels at 3 uM after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 13. | ALA4039419 | B | Binding affinity to c-myc G-quadruplex DNA in human HT cells assessed as downregulation of MYC mRNA levels at 3 uM after 24 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | cell-based format | Scientific Literature | |
| 14. | ALA4039420 | B | Stabilization of c-myc G-quadruplex DNA in MYC translocation-positive and BCL2 amplification-positive human U2932 cells assessed as potentiation of CPA-induced cytotoxicity by measuring CPA IC50 at 3 uM after 96 hrs by MTS assay (Rvb = 12.2 +/- 0.3 mM) | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 15. | ALA4039421 | B | Stabilization of c-myc G-quadruplex DNA in BCL2 and MYC translocation-positive human VAL cells assessed as potentiation of CPA-induced cytotoxicity by measuring CPA IC50 at 3 uM after 96 hrs by MTS assay (Rvb = 5.9 +/- 0.3 mM) | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 16. | ALA4039422 | B | Binding affinity to c-myc G-quadruplex DNA in human HT cells assessed as downregulation of MYC mRNA levels at 0.25 to 3 uM after 6 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | cell-based format | Scientific Literature | |
| 17. | ALA4039423 | B | Binding affinity to c-myc G-quadruplex DNA in BCL2 translocation-positive human SUDHL4 cells assessed as downregulation of MYC mRNA levels at 0.25 to 3 uM after 6 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 18. | ALA4039424 | B | Binding affinity to c-myc G-quadruplex DNA in human VAL cells assessed as downregulation of MYC mRNA levels at 0.25 to 3 uM after 6 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | cell-based format | Scientific Literature | |
| 19. | ALA4039425 | B | Binding affinity to c-myc G-quadruplex DNA in MYC translocation-positive and BCL2 amplification-positive human U2932 cells assessed as downregulation of MYC mRNA levels at 0.25 to 3 uM after 6 hrs by qPCR method | Homo sapiens | 1 | ALA4038303 | assay format | Scientific Literature | |
| 20. | ALA4039426 | F | Potentiation of CPA-induced antitumor activity against human U2932 cells xenografted in SCID mouse assessed as reduction in tumor burden at 2.5 mg/kg, ip administered for 5 consecutive days measured up to 10 days post first treatement | Homo sapiens | 1 | ALA4038303 | organism-based format | Scientific Literature |
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