| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4037806 | A | Half life in human liver microsomes at 10 uM by LC-MS/MS analysis | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 2. | ALA4037807 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS analysis | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 3. | ALA4037808 | A | Half life in mouse liver microsomes at 10 uM by LC-MS/MS analysis | Mus musculus | 26 | assay format | Scientific Literature | ||
| 4. | ALA4037809 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS analysis | Mus musculus | 26 | assay format | Scientific Literature | ||
| 5. | ALA4037825 | A | Drug metabolism in human liver microsomes assessed as CYP450 mediated-O-demethylated 7-hydroxy-2-(6-hydroxypyridin-3-yl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one metabolite formation after 60 mins by LC-MS analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA4037828 | A | Drug metabolism in mouse liver microsomes assessed as CYP450 mediated-O-demethylated 7-hydroxy-2-(6-hydroxypyridin-3-yl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one metabolite formation after 60 mins by LC-MS analysis | Mus musculus | 2 | assay format | Scientific Literature | ||
| 7. | ALA4037829 | A | Drug metabolism in human liver microsomes assessed as CYP450 mediated-O-demethylated 2-(6-hydroxy-3-pyridyl)-7-(trideuteriomethoxy)-5H-pyrazolo[4,3-c]quinolin-3-one metabolite formation after 60 mins by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4037830 | A | Drug metabolism in human liver microsomes assessed as CYP450 mediated-O-demethylated 7-hydroxy-2-(6-methoxypyridin-3-yl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one metabolite formation after 60 mins by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4037832 | A | Drug metabolism in mouse liver microsomes assessed as CYP450 mediated-O-demethylated 2-(6-hydroxy-3-pyridyl)-7-(trideuteriomethoxy)-5H-pyrazolo[4,3-c]quinolin-3-one metabolite formation after 60 mins by LC-MS analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 10. | ALA4037833 | A | Drug metabolism in mouse liver microsomes assessed as CYP450 mediated-O-demethylated 7-hydroxy-2-(6-methoxypyridin-3-yl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one metabolite formation after 60 mins by LC-MS analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 11. | ALA4037850 | A | Cytotoxicity against HEK293T cells assessed as reduction in cell viability up to 400 uM after 48 hrs by CellTiter-Glo assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 12. | ALA4037851 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability up to 400 uM after 48 hrs by CellTiter-Glo assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 13. | ALA4037852 | T | Neurotoxicity in Swiss Webster mouse assessed as induction of motor impairment at 40 mg/kg administered via oral gavage measured after 10 to 60 mins by rotarod method | Mus musculus | 18 | organism-based format | Scientific Literature | ||
| 14. | ALA4037854 | A | Cmax in Wistar rat plasma at 10 mg/kg, ip administered as single dose measured at 5 to 720 mins post dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 15. | ALA4037855 | A | Tmax in Wistar rat plasma at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 16. | ALA4037856 | A | AUC (0 to 12 hrs) in Wistar rat plasma at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 17. | ALA4037857 | A | Terminal elimination half-life in Wistar rat plasma at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 18. | ALA4037858 | A | Cmax in Wistar rat brain at 10 mg/kg, ip administered as single dose measured at 5 to 720 mins post dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 19. | ALA4037859 | A | Tmax in Wistar rat brain at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 20. | ALA4037860 | A | AUC (0 to 12 hrs) in Wistar rat brain at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature |
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