# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4014783 | Functional | Antidiabetic activity in HFD-fed C57BL/6 mouse assessed as decrease in blood glucose level at 10 mg/kg, po | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
2. | ALA4014784 | ADME | Ratio of drug level in HFD-fed C57BL/6 mouse liver to plasma at 10 mg/kg, po measured 4 hrs post dose | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
3. | ALA4014785 | ADME | Total drug level in HFD-fed C57BL/6 mouse plasma at 10 mg/kg, po measured 4 hrs post dose | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
4. | ALA4014786 | ADME | Total drug level in HFD-fed C57BL/6 mouse pancreas at 10 mg/kg, po measured 4 hrs post dose | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
5. | ALA4014787 | ADME | Total drug level in HFD-fed C57BL/6 mouse liver at 10 mg/kg, po measured 4 hrs post dose | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
6. | ALA4014789 | Toxicity | Toxicity in HFD-fed C57BL/6 mouse assessed as increase in plasma insulin level at 10 mg/kg, po | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
7. | ALA4014791 | Binding | Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH coupled spectrophotometric assay | Homo sapiens | 7 | ALA4014286 | single protein format | Scientific Literature | |
8. | ALA4014792 | Binding | Activation of recombinant human glucokinase assessed as conversion of D-glucose to D-glucose-6-phosphate in presence of 10 mM glucose by G6PDH coupled spectrophotometric assay relative to control | Homo sapiens | 7 | ALA4014286 | single protein format | Scientific Literature | |
9. | ALA4014793 | ADME | Clearance in rat | Rattus norvegicus | 7 | ALA4014286 | assay format | Scientific Literature | |
10. | ALA4014794 | ADME | Mean residence time in rat | Rattus norvegicus | 7 | ALA4014286 | assay format | Scientific Literature | |
11. | ALA4014795 | ADME | Half life in rat | Rattus norvegicus | 7 | ALA4014286 | assay format | Scientific Literature | |
12. | ALA4014796 | ADME | Oral bioavailability in rat | Rattus norvegicus | 7 | ALA4014286 | organism-based format | Scientific Literature | |
13. | ALA4014797 | Physicochemical | Apparent permeability of the compound | 7 | ALA4014286 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4014798 | ADME | Ratio of drug level in HFD-fed C57BL/6 mouse pancreas to plasma at 10 mg/kg, po measured 4 hrs post dose | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature | |
15. | ALA4014799 | ADME | Ratio of drug level in HFD-fed C57BL/6 mouse liver to pancreas at 10 mg/kg, po measured 4 hrs post dose | Mus musculus | 2 | ALA4014286 | organism-based format | Scientific Literature |