# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4037524 | B | Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV protease tagged human CXCL1-stimulated beta-arrestin recruitment by CCF4-AM-fluorescence based FRET assay | Homo sapiens | 67 | cell-based format | Scientific Literature | ||
2. | ALA4037525 | P | Solubility of compound in fasted state simulated intestinal fluid measured after 4 hrs | 33 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4037526 | A | Efflux ratio of passive permeability in MDCK2-MDR1 cells transduced with BacMam2-BCRP at 3 uM after 90 mins by Transwell assay | Canis lupus familiaris | 26 | cell-based format | Scientific Literature | ||
4. | ALA4037527 | A | Passive permeability in MDCK2-MDR1 cells transduced with BacMam2-BCRP at 3 uM after 90 mins by Transwell assay | Canis lupus familiaris | 33 | cell-based format | Scientific Literature | ||
5. | ALA4037528 | B | Antagonist activity at CXCR2 in human whole blood assessed as inhibition of GROalpha-stimulated CD11b upregulation preincubated for 15 mins followed by GROalpha stimulation measured after 15 mins by FITC-staining based FACS analysis | Homo sapiens | 34 | single protein format | Scientific Literature | ||
6. | ALA4037529 | A | Fraction unbound in Han-Wistar SOA rat model brain at 2 mg/kg administered via oral gavage by UPLC/MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
7. | ALA4037530 | A | Fraction unbound in Han-Wistar SOA rat model blood at 2 mg/kg administered via oral gavage by UPLC/MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
8. | ALA4037531 | A | Dose normalized AUC (0 to 7 hrs) in Han-Wistar SOA rat model blood at 2 mg/kg administered via oral gavage by UPLC/MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
9. | ALA4037532 | A | Dose normalized AUC (0 to 7 hrs) in Han-Wistar SOA rat model brain at 2 mg/kg administered via oral gavage by UPLC/MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
10. | ALA4037533 | A | Ratio of brain dose normalized AUC (0 to 7 hrs) to plasma dose normalized AUC (0 to 7 hrs), Kp of the compound in Han-Wistar SOA rat model at 2 mg/kg administered via oral gavage by UPLC/MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
11. | ALA4037534 | A | Unbound brain-to-blood concentration ratio in Han-Wistar SOA rat model at 2 mg/kg administered via oral gavage by UPLC/MS/MS analysis | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
12. | ALA4037535 | A | Clearance in Wistar rat blood at 1.01 mg/kg, iv measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
13. | ALA4037536 | A | Volume of distribution at steady state in Wistar rat at 1.01 mg/kg, iv measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
14. | ALA4037537 | A | Elimination half life in Wistar rat at 1.01 mg/kg, iv measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4037538 | A | Dose normalized AUC (0 to infinity) in Wistar rat at 1.01 mg/kg, iv measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4037539 | A | Tmax in Wistar rat at 2.38 mg/kg, po measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4037540 | A | Cmax in Wistar rat at 2.38 mg/kg, po measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4037541 | A | Dose normalized AUC (0 to infinity) in Wistar rat at 2.38 mg/kg, po measured up to 4 hrs post dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4037542 | A | Oral bioavailability in Wistar rat at 2.38 mg/kg measured up to 4 hrs after dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature |