# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4028677 | T | Toxicity in mouse assessed as effect on survival at 160 mg/kg, po administered for 3 days measured after 30 days | Mus musculus | 4 | ALA4024803 | organism-based format | Scientific Literature | |
2. | ALA4028678 | B | Inhibition of Clostridium botulinum BoNT/A light chain at 20 uM using P39 as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by HPLC method relative to control | Clostridium botulinum | 42 | ALA4024803 | single protein format | Scientific Literature | |
3. | ALA4028679 | B | Inhibition of Clostridium botulinum BoNT/A light chain using P39 as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by HPLC method | Clostridium botulinum | 20 | ALA4024803 | single protein format | Scientific Literature | |
4. | ALA4028680 | B | Inhibition of Clostridium botulinum BoNT/A holotoxin-mediated SNAP-25 cleavage in mouse HBG3 cell-derived motor neurons assessed as full length of SNAP-25 at 10 uM preincubated for 30 mins followed by intoxication measured after 4 hrs by Western blot method relative to control | Clostridium botulinum | 30 | ALA4024803 | single protein format | Scientific Literature | |
5. | ALA4028681 | B | Inhibition of Clostridium botulinum BoNT/A holotoxin-mediated SNAP-25 cleavage in mouse HBG3 cell-derived motor neurons assessed as full length of SNAP-25 at 20 uM preincubated for 30 mins followed by intoxication measured after 4 hrs by Western blot method relative to control | Clostridium botulinum | 29 | ALA4024803 | single protein format | Scientific Literature | |
6. | ALA4028684 | B | Inhibition of Clostridium botulinum BoNT/A holotoxin-mediated SNAP-25 cleavage in mouse HBG3 cell-derived motor neurons preincubated for 30 mins followed by intoxication measured after 4 hrs by Western blot method | Clostridium botulinum | 30 | ALA4024803 | single protein format | Scientific Literature | |
7. | ALA4028685 | B | Inhibition of Clostridium botulinum BoNT/A holotoxin-mediated SNAP-25 cleavage in mouse HBG3 cell-derived motor neurons assessed as full length of SNAP-25 at 20 uM treated at 30 mins post intoxication by Western blot method relative to control | Clostridium botulinum | 10 | ALA4024803 | single protein format | Scientific Literature | |
8. | ALA4028686 | B | Inhibition of Clostridium botulinum BoNT/A holotoxin-mediated SNAP-25 cleavage in mouse HBG3 cell-derived motor neurons assessed as full length of SNAP-25 at 20 uM treated at 60 mins post intoxication by Western blot method relative to control | Clostridium botulinum | 10 | ALA4024803 | single protein format | Scientific Literature | |
9. | ALA4028691 | T | Toxicity in mouse assessed as effect on appearance at 160 mg/kg, po administered for 3 days measured 2 times a day for 30 days | Mus musculus | 4 | ALA4024803 | organism-based format | Scientific Literature | |
10. | ALA4028692 | T | Toxicity in mouse assessed as effect on behavior at 160 mg/kg, po administered for 3 days measured 2 times a day for 30 days | Mus musculus | 4 | ALA4024803 | organism-based format | Scientific Literature | |
11. | ALA4028696 | P | Distribution co-efficient, log D of the compound at pH 1 by reversed-phase thin-layer chromatographic method | 12 | ALA4024803 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4199595 | F | Antileishmanial activity against Leishmania infantum MHOM/TN/80/IPT1 promastigotes after 72 hrs by MTT assay | Leishmania infantum | 31 | ALA4196114 | organism-based format | Scientific Literature | |
13. | ALA4199596 | F | Antileishmanial activity against Leishmania tropica MHOM/IT/2012/ISS3130 promastigotes after 72 hrs by MTT assay | Leishmania tropica | 31 | ALA4196114 | organism-based format | Scientific Literature | |
14. | ALA4199597 | A | Cytotoxicity against PMA-differentiated human THP1 cells after 72 hrs by MTT assay | Homo sapiens | 31 | ALA4196114 | cell-based format | Scientific Literature | |
15. | ALA4199598 | T | Selectivity index, ratio of IC50 for PMA-differentiated human THP1 cells to IC50 for Leishmania infantum MHOM/TN/80/IPT1 promastigotes | 31 | ALA4196114 | assay format | Scientific Literature | ||
16. | ALA4199599 | T | Selectivity index, ratio of IC50 for PMA-differentiated human THP1 cells to IC50 for Leishmania tropica MHOM/IT/2012/ISS3130 promastigotes | 31 | ALA4196114 | assay format | Scientific Literature |