# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4054819 | Binding | Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assay | Homo sapiens | 33 | ALA4052645 | single protein format | Scientific Literature | |
2. | ALA4054820 | Binding | Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assay | Homo sapiens | 33 | ALA4052645 | single protein format | Scientific Literature | |
3. | ALA4054821 | Binding | Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting method | Homo sapiens | 33 | ALA4052645 | single protein format | Scientific Literature | |
4. | ALA4054822 | ADME | Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assay | Homo sapiens | 33 | ALA4052645 | single protein format | Scientific Literature | |
5. | ALA4054823 | Unassigned | Selectivity ratio of IC50 for JAK2 dependent EPO-induced STAT5A phosphorylation in human TF1 cells to IC50 for JAK1/JAK3 dependent IL2-induced STAT3 phosphorylation in human PBMC derived T-cells | Homo sapiens | 28 | ALA4052645 | cell-based format | Scientific Literature | |
6. | ALA4054824 | Binding | Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISA | Homo sapiens | 33 | ALA4052645 | protein complex format | Scientific Literature | |
7. | ALA4054833 | Functional | In vivo inhibition of JAK1/JAK3 in Balb/c mouse assessed as reduction in IL15-induced STAT5 phosphorylation at 5 mg/ml, po after 4 hrs | Mus musculus | 2 | ALA4052645 | organism-based format | Scientific Literature | |
8. | ALA4054843 | Binding | Inhibition of human ERG by patch clamp method | Homo sapiens | 2 | ALA4052645 | assay format | Scientific Literature | |
9. | ALA4054844 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4052645 | single protein format | Scientific Literature | |
10. | ALA4054845 | Binding | Inhibition of human ERG by flux-based assay | Homo sapiens | 28 | ALA4052645 | single protein format | Scientific Literature | |
11. | ALA4054848 | ADME | Permeability from apical side to basolateral side in human Caco2 cells | Homo sapiens | 5 | ALA4052645 | cell-based format | Scientific Literature | |
12. | ALA4054849 | ADME | Metabolic stability in mouse liver microsomes assessed as compound remaining after 10 mins | Mus musculus | 5 | ALA4052645 | assay format | Scientific Literature | |
13. | ALA4054850 | ADME | Protein binding in mouse plasma at 10 mg/kg, po | Mus musculus | 5 | ALA4052645 | organism-based format | Scientific Literature | |
14. | ALA4054852 | ADME | Cmax in mouse at 10 mg/kg, po after 24 hrs | Mus musculus | 1 | ALA4052645 | organism-based format | Scientific Literature | |
15. | ALA4054854 | ADME | Cmin in mouse at 10 mg/kg, po after 24 hrs | Mus musculus | 1 | ALA4052645 | organism-based format | Scientific Literature | |
16. | ALA4054855 | ADME | Half life in human liver microsomes | Homo sapiens | 1 | ALA4052645 | assay format | Scientific Literature | |
17. | ALA4054856 | ADME | Activation of PXR (unknown origin) | Homo sapiens | 1 | ALA4052645 | single protein format | Scientific Literature | |
18. | ALA4054857 | Binding | Inhibition of calcium channel (unknown origin) at 10 uM by patch clamp assay | Homo sapiens | 1 | ALA4052645 | assay format | Scientific Literature | |
19. | ALA4054858 | Binding | Inhibition of sodium channel (unknown origin) at 10 uM by patch clamp assay | Homo sapiens | 1 | ALA4052645 | assay format | Scientific Literature | |
20. | ALA4054859 | ADME | Protein binding in human plasma | Homo sapiens | 1 | ALA4052645 | cell-free format | Scientific Literature |