| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4054819 | B | Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assay | Homo sapiens | 33 | single protein format | Scientific Literature | ||
| 2. | ALA4054820 | B | Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assay | Homo sapiens | 33 | single protein format | Scientific Literature | ||
| 3. | ALA4054821 | B | Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting method | Homo sapiens | 33 | single protein format | Scientific Literature | ||
| 4. | ALA4054822 | A | Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assay | Homo sapiens | 33 | single protein format | Scientific Literature | ||
| 5. | ALA4054823 | U | Selectivity ratio of IC50 for JAK2 dependent EPO-induced STAT5A phosphorylation in human TF1 cells to IC50 for JAK1/JAK3 dependent IL2-induced STAT3 phosphorylation in human PBMC derived T-cells | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 6. | ALA4054824 | B | Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISA | Homo sapiens | 33 | protein complex format | Scientific Literature | ||
| 7. | ALA4054833 | F | In vivo inhibition of JAK1/JAK3 in Balb/c mouse assessed as reduction in IL15-induced STAT5 phosphorylation at 5 mg/ml, po after 4 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA4054843 | B | Inhibition of human ERG by patch clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 9. | ALA4054844 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA4054845 | B | Inhibition of human ERG by flux-based assay | Homo sapiens | 28 | single protein format | Scientific Literature | ||
| 11. | ALA4054848 | A | Permeability from apical side to basolateral side in human Caco2 cells | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA4054849 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining after 10 mins | Mus musculus | 5 | assay format | Scientific Literature | ||
| 13. | ALA4054850 | A | Protein binding in mouse plasma at 10 mg/kg, po | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 14. | ALA4054852 | A | Cmax in mouse at 10 mg/kg, po after 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4054854 | A | Cmin in mouse at 10 mg/kg, po after 24 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4054855 | A | Half life in human liver microsomes | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4054856 | A | Activation of PXR (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4054857 | B | Inhibition of calcium channel (unknown origin) at 10 uM by patch clamp assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4054858 | B | Inhibition of sodium channel (unknown origin) at 10 uM by patch clamp assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4054859 | A | Protein binding in human plasma | Homo sapiens | 1 | cell-free format | Scientific Literature |
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