| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3994678 | Functional | Induction of apoptosis in human MCF7 cells assessed as viable cells at 12.76 +/- 0.46 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric method (Rvb = 83.4%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 2. | ALA3994679 | Functional | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | Homo sapiens | 17 | ALA3994561 | cell-based format | Scientific Literature | |
| 3. | ALA3994680 | Functional | Cytotoxicity against human NALM6 cells after 48 hrs by MTT assay | Homo sapiens | 17 | ALA3994561 | cell-based format | Scientific Literature | |
| 4. | ALA3994681 | Functional | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | Homo sapiens | 17 | ALA3994561 | cell-based format | Scientific Literature | |
| 5. | ALA3994682 | ADME | Cytotoxicity against human HUVEC cells after 48 hrs by MTT assay | Homo sapiens | 2 | ALA3994561 | cell-based format | Scientific Literature | |
| 6. | ALA3994683 | ADME | Cytotoxicity against human MCF10A cells after 48 hrs by MTT assay | Homo sapiens | 2 | ALA3994561 | cell-based format | Scientific Literature | |
| 7. | ALA3994684 | Functional | Induction of apoptosis in human MCF7 cells assessed as early apoptotic cells at 12.76 +/- 0.46 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric method (Rvb = 1.7%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 8. | ALA3994685 | Functional | Induction of apoptosis in human MCF7 cells assessed as late apoptotic cells at 12.76 +/- 0.46 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric method (Rvb = 10.1 +/- 0.2%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 9. | ALA3994686 | Functional | Induction of apoptosis in human MCF7 cells assessed as necrotic cells at 12.76 +/- 0.46 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric method (Rvb = 4.1%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 10. | ALA3994687 | Functional | Induction of apoptosis in human MCF7 cells assessed as upregulation of caspase-3 mRNA level at 12.76 +/- 0.46 uM by quantitative real-time PCR method | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 11. | ALA3994688 | Functional | Induction of apoptosis in human MCF7 cells assessed as upregulation of Bax mRNA level at 12.76 +/- 0.46 uM by quantitative real-time PCR method | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 12. | ALA3994689 | Functional | Induction of apoptosis in human MCF7 cells assessed as downregulation of Bcl-2 mRNA level at 12.76 +/- 0.46 uM by quantitative real-time PCR method | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 13. | ALA3994690 | Functional | Cell cycle arrest in human MCF7 cells assessed as accumulation at sub G0/G1 phase at 12.76 +/- 0.46 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 1.3%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 14. | ALA3994691 | Functional | Disruption of mitochondrial membrane potential in human MCF7 cells assessed as collapse of the mitochondrial membrane potential at 12.76 +/- 0.46 uM after 24 hrs by JC10 staining-based flow cytometric method (Rvb = 23.9%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 15. | ALA3994692 | Functional | Disruption of mitochondrial membrane potential in human MCF7 cells assessed as intact mitochondrial membrane at 12.76 +/- 0.46 uM after 24 hrs by JC10 staining-based flow cytometric method (Rvb = 76.1%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 16. | ALA3994693 | Functional | Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 12.76 +/- 0.46 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 52.2%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 17. | ALA3994694 | Functional | Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 12.76 +/- 0.46 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 25.9%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 18. | ALA3994695 | Functional | Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 12.76 +/- 0.46 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 20.3%) | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 19. | ALA3994696 | Functional | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | Homo sapiens | 1 | ALA3994561 | cell-based format | Scientific Literature | |
| 20. | ALA3994697 | Functional | Selectivity index, ratio of IC50 for human MCF10A cells to IC50 for human MCF7 cells | Homo sapiens | 1 | ALA3994561 | assay format | Scientific Literature |
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