| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4030854 | B | Inhibition of UbcH5c (unknown origin) expressed in human 293T cells assessed as decrease in TNF-alpha-mediated NF-kB activation at 5 uM preincubated for 2 hrs followed by TNF-alpha stimulation for 8 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 2. | ALA4030855 | A | Cytotoxicity against human 293T cells assessed as inhibition of cell viability at 5 uM by CCK-8 assay relative to control | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 3. | ALA4030871 | B | Inhibition of UbcH5c (unknown origin) at 5 uM preincubated for 15 mins followed by E1, Ub and ATP addition measured after 40 mins by Western blot analysis | Homo sapiens | 52 | single protein format | Scientific Literature | ||
| 4. | ALA4030896 | B | Inhibition of UbcH5c in mouse b.End3 cells assessed as decrease in TNF-alpha-mediated IkB-alpha phosphorylation at 10 uM preincubated for 2 hrs followed by TNF-alpha stimulation for 20 mins by Western blot analysis | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA4030897 | B | Inhibition of UbcH5c in mouse b.End3 cells assessed as decrease in TNF-alpha-mediated IkB-alpha degradation at 10 uM preincubated for 2 hrs followed by TNF-alpha stimulation for 20 mins by Western blot analysis | Mus musculus | 10 | cell-based format | Scientific Literature |
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