# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3992284 | B | Binding affinity to recombinant full-length N-terminal hexahistidine-tagged c-Myc (353 to 437 residues) bHLH-ZIP domain (unknown origin) expressed in Escherichia coli BL21 DE3 (pLysS) by fluorescence polarization assay | Homo sapiens | 27 | ALA3991946 | assay format | Patent Bioactivity Data | |
2. | ALA3992286 | B | Binding affinity to human hexahistidine-tagged Max p21 bHLH-ZIP domain expressed in Escherichia coli M15 (pRep4) at 10 uM by fluorescence polarization assay | Homo sapiens | 6 | ALA3991946 | assay format | Patent Bioactivity Data | |
3. | ALA3992289 | B | Binding affinity to recombinant full-length N-terminal hexahistidine-tagged c-Myc (353 to 437 residues) bHLH-ZIP domain (unknown origin) expressed in Escherichia coli BL21 DE3 (pLysS) assessed as changes in shape or intensity of CD spectrum at 5 uM by circular dichroism assay | Homo sapiens | 6 | ALA3991946 | assay format | Patent Bioactivity Data | |
4. | ALA3992294 | B | Inhibition of recombinant full-length N-terminal hexahistidine-tagged c-Myc (353 to 437 residues) bHLH-ZIP domain (unknown origin) expressed in Escherichia coli BL21 DE3 (pLysS)/human hexahistidine-tagged Max p21 expressed in Escherichia coli M15 (pRep4) assessed as disruption of E-Box DNA binding preincubated for 30 mins with c-Myc followed by Max p21 and E-box element addition measured after 15 mins by electrophoretic mobility shift assay | Homo sapiens | 6 | ALA3991946 | assay format | Patent Bioactivity Data | |
5. | ALA3992296 | F | Cytotoxicity against human HL60 cells expressing c-Myc assessed as growth inhibition after 4 to 5 days by MTT assay | Homo sapiens | 16 | ALA3991946 | cell-based format | Patent Bioactivity Data | |
6. | ALA3992297 | F | Cytotoxicity against human Daudi Burkitt lymphoma cells expressing c-Myc assessed as growth inhibition after 4 to 5 days by MTT assay | Homo sapiens | 15 | ALA3991946 | cell-based format | Patent Bioactivity Data | |
7. | ALA3992298 | A | Cytotoxicity against non-transformed rat TGR1 assessed as growth inhibition after 4 to 5 days by MTT assay | Rattus norvegicus | 11 | ALA3991946 | cell-based format | Patent Bioactivity Data | |
8. | ALA3992299 | A | Cytotoxicity against c-Myc null rat TGR1 reconstituted with HMGA1b or MT-MC1 assessed as growth inhibition after 4 to 5 days by MTT assay | Rattus norvegicus | 11 | ALA3991946 | cell-based format | Patent Bioactivity Data | |
9. | ALA3992300 | B | Inhibition of recombinant c-Myc/Max (unknown origin) expressed in human HL60 cells assessed as disruption of c-Myc/Max association after 6 hrs by co-immunoprecipitation assay | Homo sapiens | 4 | ALA3991946 | cell-based format | Patent Bioactivity Data | |
10. | ALA3992301 | B | Inhibition of recombinant c-Myc/Max (unknown origin) expressed in human HL60 cells assessed as disruption of c-Myc/Max association after 16 hrs by co-immunoprecipitation assay | Homo sapiens | 4 | ALA3991946 | cell-based format | Patent Bioactivity Data | |
11. | ALA3992302 | U | Metabolic stability of the compound | 5 | ALA3991946 | assay format | Patent Bioactivity Data |