# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4030998 | Binding | Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase reporter gene assay | Mus musculus | 80 | ALA4028856 | cell-based format | Scientific Literature | |
2. | ALA4031000 | Binding | Inhibition of binding of mouse GATA4 to [32P]-double stranded oligonucleotide expressed in African green monkey COS-1 cells at 50 uM preincubated for 10 mins followed by [32P]-double stranded oligonucleotide addition measured after 20 mins by EMSA method | Mus musculus | 3 | ALA4028856 | cell-based format | Scientific Literature | |
3. | ALA4031001 | Binding | Inhibition of binding of mouse NKX2-5 to [32P]-double stranded oligonucleotide expressed in African green monkey COS-1 cells at 50 uM preincubated for 10 mins followed by [32P]-double stranded oligonucleotide addition measured after 20 mins by EMSA method | Mus musculus | 3 | ALA4028856 | cell-based format | Scientific Literature | |
4. | ALA4031002 | Binding | Inhibition of binding of GATA4 to [32P]-double stranded oligonucleotide in neonatal rat ventricular cardiomyocytes at 50 uM measured after 24 hrs by EMSA method | Rattus norvegicus | 2 | ALA4028856 | assay format | Scientific Literature | |
5. | ALA4031003 | Binding | Inhibition of binding of NKX2-5 to [32P]-double stranded oligonucleotide in neonatal rat ventricular cardiomyocytes at 50 uM measured after 24 hrs by EMSA method | Rattus norvegicus | 1 | ALA4028856 | assay format | Scientific Literature | |
6. | ALA4031009 | ADME | Induction of necrosis in endothelin-1 induced neonatal rat ventricular cardiomyocytes assessed as release of adenylate kinase at 50 uM measured after 24 hrs by bioluminescence assay | Rattus norvegicus | 3 | ALA4028856 | cell-based format | Scientific Literature | |
7. | ALA4031010 | ADME | Induction of apoptosis in endothelin-1 induced neonatal rat ventricular cardiomyocytes at 50 uM measured after 24 hrs by TUNEL assay | Rattus norvegicus | 3 | ALA4028856 | cell-based format | Scientific Literature | |
8. | ALA4031013 | Binding | Inhibiton of human FGFR3 at 30 uM | Homo sapiens | 1 | ALA4028856 | single protein format | Scientific Literature | |
9. | ALA4031030 | Unassigned | Induction of aggregation of compounds at 100 uM by nephalometric method | 3 | ALA4028856 | assay format | Scientific Literature | ||
10. | ALA4031034 | Binding | Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells at 50 uM measured after 30 hrs by dual luciferase reporter gene assay | Mus musculus | 1 | ALA4028856 | cell-based format | Scientific Literature | |
11. | ALA4031035 | Unassigned | Induction of aggregation of compound at 3 to 30 uM by nephalometric method | 2 | ALA4028856 | assay format | Scientific Literature | ||
12. | ALA4031036 | Binding | Inhibition of mouse GATA4-driven transactivation of luciferase reporter construct containing BNP minimal promoter expressed in African green monkey COS-1 cells after 30 hrs by luminometer | Mus musculus | 2 | ALA4028856 | cell-based format | Scientific Literature | |
13. | ALA4031037 | Binding | Inhibition of mouse GATA4-driven transactivation of luciferase reporter construct containing BNP minimal promoter with tandem GATA-site on -90 bp expressed in African green monkey COS-1 cells after 30 hrs by luminometer | Mus musculus | 2 | ALA4028856 | cell-based format | Scientific Literature | |
14. | ALA4031043 | Binding | Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of ANP at 100 uM after 24 hrs by real-time PCR analysis relative to control | Rattus norvegicus | 1 | ALA4028856 | assay format | Scientific Literature | |
15. | ALA4031044 | Binding | Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of BNP at 100 uM after 24 hrs by real-time PCR analysis relative to control | Rattus norvegicus | 1 | ALA4028856 | assay format | Scientific Literature | |
16. | ALA4031045 | ADME | Induction of necrosis in neonatal rat ventricular cardiomyocytes assessed as release of adenylate kinase at 50 uM measured after 24 hrs by bioluminescence assay | Rattus norvegicus | 3 | ALA4028856 | cell-based format | Scientific Literature |