# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4047127 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 1 to 2 uM after 6 hrs by Western blot analysis | Homo sapiens | 9 | ALA4043223 | cell-based format | Scientific Literature | |
2. | ALA4047128 | ADME | Cytotoxicity against human RPMI8226 cells at 1 to 2 uM after 6 hrs by MTT assay | Homo sapiens | 1 | ALA4043223 | cell-based format | Scientific Literature | |
3. | ALA4047130 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 0.05 to 0.2 uM after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4043223 | cell-based format | Scientific Literature | |
4. | ALA4047131 | ADME | Cytotoxicity against human RPMI8226 cells at 0.5 uM after 6 hrs by MTT assay | Homo sapiens | 1 | ALA4043223 | cell-based format | Scientific Literature | |
5. | ALA4047132 | ADME | Cytotoxicity against human RPMI8226 cells at 0.05 to 0.2 uM after 6 hrs by MTT assay | Homo sapiens | 1 | ALA4043223 | cell-based format | Scientific Literature | |
6. | ALA4047134 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 0.5 uM after 6 hrs by Western blot analysis relative to NSC126405 | Homo sapiens | 28 | ALA4043223 | cell-based format | Scientific Literature | |
7. | ALA4047135 | Functional | Cytotoxicity against human RPMI8226 cells after 48 hrs by MTT assay | Homo sapiens | 29 | ALA4043223 | cell-based format | Scientific Literature | |
8. | ALA4047136 | Functional | Cytotoxicity against human MM1S cells after 48 hrs by MTT assay | Homo sapiens | 29 | ALA4043223 | cell-based format | Scientific Literature | |
9. | ALA4418216 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p70 phosphorylation incubated for 6 hrs by Western blot analysis | Homo sapiens | 9 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
10. | ALA4418217 | ADME | Induction of p70 degradation in human RPMI8226 cells at 1 to 2 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
11. | ALA4418218 | Toxicity | Toxicity in human RPMI8226 cells at 1 to 2 uM incubated for 6 hrs | Homo sapiens | 1 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
12. | ALA4418219 | Toxicity | Toxicity in human RPMI8226 cells at 0.5 uM incubated for 6 hrs | Homo sapiens | 1 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
13. | ALA4418220 | Toxicity | Toxicity in human RPMI8226 cells at 0.05 to 0.2 uM incubated for 6 hrs | Homo sapiens | 1 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
14. | ALA4418221 | Functional | Cytotoxicity in human RPMI8226 cells incubated for 48 hrs by MTT assay | Homo sapiens | 29 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
15. | ALA4418222 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p70 phosphorylation at 0.5 uM incubated for 6 hrs by Western blot analysis relative to Perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine | Homo sapiens | 29 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
16. | ALA4418223 | Functional | Cytotoxicity in human MM1S cells incubated for 48 hrs by MTT assay | Homo sapiens | 29 | ALA4417640 | cell-based format | Patent Bioactivity Data |