# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4012479 | P | Solubility of the compound at pH 1.2 | 1 | ALA4011612 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4012480 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA4011612 | single protein format | Scientific Literature | |
3. | ALA4012481 | B | Inhibition of human CYP11B2 expressed in HEK293A cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition measured after 1 hr by HTRF assay | Homo sapiens | 23 | ALA4011612 | cell-based format | Scientific Literature | |
4. | ALA4012482 | B | Inhibition of mouse CYP11B2 expressed in HEK293 cells using deoxycorticosterone as substrate pretreated for 1 hr followed by substrate addition after 2 hrs by HTRF assay | Mus musculus | 22 | ALA4011612 | cell-based format | Scientific Literature | |
5. | ALA4012483 | A | Inhibition of human CYP11B1 expressed in HEK293A cells | Homo sapiens | 22 | ALA4011612 | cell-based format | Scientific Literature | |
6. | ALA4012484 | U | Selectivity index, ratio of IC50 for human CYP11B1 to IC50 for human CYP11B2 expressed in HEK293A cells | Homo sapiens | 15 | ALA4011612 | cell-based format | Scientific Literature | |
7. | ALA4012487 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA4011612 | single protein format | Scientific Literature | |
8. | ALA4012488 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA4011612 | single protein format | Scientific Literature | |
9. | ALA4012489 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 1 | ALA4011612 | single protein format | Scientific Literature | |
10. | ALA4012490 | B | Inhibition of CYP19 (unknown origin) at 1 uM | Homo sapiens | 1 | ALA4011612 | single protein format | Scientific Literature | |
11. | ALA4012491 | A | Metabolic stability in human liver microsomes | Homo sapiens | 1 | ALA4011612 | assay format | Scientific Literature | |
12. | ALA4012492 | A | Plasma protein binding in mouse | Mus musculus | 1 | ALA4011612 | cell-free format | Scientific Literature | |
13. | ALA4012493 | P | Solubility of the compound at pH 6.8 | 1 | ALA4011612 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4012494 | F | Decrease in plasma aldosterone level in furosemide-induced cynomolgus monkey at 3 mg/kg, po administered as single dose by radioimmunoassay | Macaca fascicularis | 1 | ALA4011612 | organism-based format | Scientific Literature | |
15. | ALA4012496 | A | Half life in cynomolgus monkey at 3 mg/kg, po administered as single dose | Macaca fascicularis | 1 | ALA4011612 | organism-based format | Scientific Literature | |
16. | ALA4012497 | A | Cmax in cynomolgus monkey at 3 mg/kg, po administered as single dose | Macaca fascicularis | 1 | ALA4011612 | organism-based format | Scientific Literature | |
17. | ALA4012498 | A | Tmax in cynomolgus monkey at 3 mg/kg, po administered as single dose | Macaca fascicularis | 1 | ALA4011612 | organism-based format | Scientific Literature | |
18. | ALA4012499 | A | Total AUC in cynomolgus monkey at 3 mg/kg, po administered as single dose | Macaca fascicularis | 1 | ALA4011612 | organism-based format | Scientific Literature |