| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3999523 | F | Antioxidant activity in FRDA patient derived lymphocytes assessed as inhibition of DEM-mediated lipid peroxidation at 0.1 to 2.5 uM pretreated for 16 hrs followed by DEM addition measured after 120 mins by C11-BODIPY581/591 probe-based FACS analysis | Homo sapiens | 13 | ALA3997815 | cell-based format | Scientific Literature | |
| 2. | ALA3999524 | F | Antioxidant activity in FRDA patient derived lymphocytes assessed as inhibition of DEM-mediated reactive oxygen species formation at 0.1 to 2.5 uM pretreated for 16 hrs followed by DEM addition measured after 80 mins by DCFH-DA dye-based flow cytometric analysis | Homo sapiens | 4 | ALA3997815 | cell-based format | Scientific Literature | |
| 3. | ALA3999526 | F | Cytoprotective activity in DEM-treated FRDA patient derived lymphocytes assessed as preservation of mitochondrial inner membrane potential at 2.5 uM pretreated for 16 hrs followed by DEM addition measured after 120 mins by TMRM dye-based flow cytometric analysis | Homo sapiens | 8 | ALA3997815 | cell-based format | Scientific Literature | |
| 4. | ALA3999528 | F | Cytoprotective activity against DEM-induced oxidative stress in FRDA patient derived lymphocytes assessed as increase in cell viability at 0.1 to 2.5 uM pretreated for 16 hrs followed by DEM addition measured after 6 hrs by calcein acetoxy-methyl-ester/ethidium homodimer-1 staining-based flow cytometric analysis | Homo sapiens | 6 | ALA3997815 | cell-based format | Scientific Literature | |
| 5. | ALA3999530 | F | Cytoprotective activity in FRDA patient derived lymphocytes cultured in glucose-free media supplemented with galactose assessed as total intracellular ATP levels at 1 uM after 48 hrs by luciferin-luciferase reaction-based bioluminescence assay relative to control | Homo sapiens | 13 | ALA3997815 | cell-based format | Scientific Literature | |
| 6. | ALA3999531 | F | Cytoprotective activity in FRDA patient derived lymphocytes cultured in glucose-free media supplemented with galactose assessed as total intracellular ATP levels at 5 uM after 48 hrs by luciferin-luciferase reaction-based bioluminescence assay relative to control | Homo sapiens | 13 | ALA3997815 | cell-based format | Scientific Literature | |
| 7. | ALA3999532 | F | Cytoprotective activity in FRDA patient derived lymphocytes cultured in glucose-free media supplemented with galactose assessed as total intracellular ATP levels at 20 uM after 48 hrs by luciferin-luciferase reaction-based bioluminescence assay relative to control | Homo sapiens | 12 | ALA3997815 | cell-based format | Scientific Literature | |
| 8. | ALA3999534 | A | Metabolic stability in bovine liver microsomes assessed as compound recovery at 25 uM after 30 mins in presence of beta-NADPH by HPLC method | Bos taurus | 9 | ALA3997815 | assay format | Scientific Literature | |
| 9. | ALA4430888 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as inhibition of DEM-induced lipid peroxidation at 0.1 to 1 uM pre-incubated for 16 hrs followed by DEM addition for 120 mins by C11-BODIPY581/591 probe based flow cytometry relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 10. | ALA4430889 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as suppression of DEM-induced intracellular ROS levels at 2.5 uM pre-incubated for 16 hrs followed by DEM addition for 80 mins by DCFH-DA probe based flow cytometry | Homo sapiens | 3 | ALA4428118 | cell-based format | Scientific Literature | |
| 11. | ALA4430890 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as suppression of DEM-induced intracellular ROS levels at 100 nM pre-incubated for 16 hrs followed by DEM addition for 80 mins by DCFH-DA probe based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 12. | ALA4430891 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as suppression of DEM-induced intracellular ROS levels pre-incubated for 16 hrs followed by DEM addition for 80 mins by DCFH-DA probe based flow cytometry | Homo sapiens | 3 | ALA4428118 | cell-based format | Scientific Literature | |
| 13. | ALA4430892 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 100 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 14. | ALA4430893 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 1000 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 15. | ALA4430894 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 2500 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 16. | ALA4430895 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 17. | ALA4430896 | A | Effect on mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 incubated for 16 hrs by TMRM dye based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 18. | ALA4430897 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 1 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 19. | ALA4430898 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 5 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
| 20. | ALA4430899 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 20 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!