# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4052329 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
2. | ALA4052332 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
3. | ALA4052333 | B | Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
4. | ALA4052334 | B | Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | assay format | Scientific Literature | ||
5. | ALA4052335 | A | Cmax in C57BL/6 mouse lung at 30 mg/kg, po by LC-MS/MS analysis | Mus musculus | 12 | organism-based format | Scientific Literature | ||
6. | ALA4052336 | A | Cmax in C57BL/6 mouse plasma at 30 mg/kg, po by LC-MS/MS analysis | Mus musculus | 12 | organism-based format | Scientific Literature | ||
7. | ALA4052343 | B | Irreversible inhibition of human LOXL2 assessed as reduction of H2O2 production from oxidative deamination of DAP at 1000 times IC50 preincubated for 2 hrs followed by compound washout and subsequent incubation for 2 hrs prior to substrate addition measured every 2 mins for 40 mins by amplex red reagent-based fluorescence assay relative to control | Homo sapiens | 10 | single protein format | Scientific Literature | ||
8. | ALA4052344 | B | Irreversible inhibition of human LOXL2 assessed as catalytic activity preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay relative to control | Homo sapiens | 10 | single protein format | Scientific Literature | ||
9. | ALA4418378 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction in amine oxidase activity incubated for 2 hrs by Amplex red based fluorescence assay | Homo sapiens | 120 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4418379 | F | Antifibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in collagen level in lung at 60 mg/kg, po pre-treated 1 hr to 1 day before bleomycin injection and measured after 14 to 28 days by hydroxyproline assay | Mus musculus | 6 | organism-based format | Patent Bioactivity Data | ||
11. | ALA4418380 | F | Antifibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in cross linked collagen level in lung at 60 mg/kg, po pre-treated 1 hr to 1 day before bleomycin injection and measured after 14 to 28 days by Masson's trichrome staining based assay | Mus musculus | 6 | organism-based format | Patent Bioactivity Data | ||
12. | ALA4418381 | F | Antifibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in cross linked collagen level in lung at 60 mg/kg, po pre-treated 1 hr to 1 day before bleomycin injection and measured after 14 to 28 days by Picro-Sirius staining based assay | Mus musculus | 6 | organism-based format | Patent Bioactivity Data | ||
13. | ALA4418382 | F | Antifibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in alpha smooth muscle actin level in lung at 60 mg/kg, po pre-treated 1 hr to 1 day before bleomycin injection and measured after 14 to 28 days by immunohistochemistry analysis | Mus musculus | 6 | organism-based format | Patent Bioactivity Data | ||
14. | ALA4418383 | F | Antifibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in hydroxyproline in lung homogenates at 60 mg/kg, po pre-treated 1 hr to 1 day before bleomycin injection and measured after 14 to 28 days by chloramine T and Erlich's solution based assay | Mus musculus | 6 | organism-based format | Patent Bioactivity Data |