# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4051356 | Binding | Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATP | Homo sapiens | 26 | ALA4049432 | single protein format | Scientific Literature | |
2. | ALA4051357 | Binding | Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATP | Homo sapiens | 27 | ALA4049432 | single protein format | Scientific Literature | |
3. | ALA4051358 | Binding | Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levels | Homo sapiens | 29 | ALA4049432 | cell-based format | Scientific Literature | |
4. | ALA4051359 | Binding | Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levels | Homo sapiens | 29 | ALA4049432 | cell-based format | Scientific Literature | |
5. | ALA4051360 | Physicochemical | Octanol-aqueous phosphate buffer distribution coefficient, log D of the compound at pH 7.4 | 26 | ALA4049432 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4051361 | Physicochemical | Aqueous solubility of compound in pH 7.4 solution after 24 hrs | 26 | ALA4049432 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4051363 | Binding | Inhibition of MEK1 (unknown origin) | Homo sapiens | 29 | ALA4049432 | single protein format | Scientific Literature | |
8. | ALA4051364 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 25 | ALA4049432 | assay format | Scientific Literature | |
9. | ALA4051365 | ADME | Intrinsic clearance in rat hepatocytes assessed as per million cells | Rattus norvegicus | 20 | ALA4049432 | cell-based format | Scientific Literature | |
10. | ALA4051366 | ADME | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 2 | ALA4049432 | cell-based format | Scientific Literature | |
11. | ALA4051367 | ADME | Efflux ratio of apparent permeability in human Caco2 cells | Homo sapiens | 15 | ALA4049432 | cell-based format | Scientific Literature |