| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993207 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as compound concentration required to induce up to 3-fold leftward shift in glycine-induced increase in chloride ion flux after 4 mins by Schild plot analysis | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA3993208 | A | Intrinsic clearance in mouse liver microsomes up to 40 mins in presence of NADPH | Mus musculus | 23 | assay format | Scientific Literature | ||
| 3. | ALA3993209 | A | Passive apparent permeability in MDCK cells | Canis lupus familiaris | 15 | cell-based format | Scientific Literature | ||
| 4. | ALA3993210 | A | Efflux ratio of passive apparent permeability in MDCK cells harboring human MDR1 | Canis lupus familiaris | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA3993211 | A | Efflux ratio of passive apparent permeability in MDCK cells harboring human BCRP | Canis lupus familiaris | 14 | cell-based format | Scientific Literature | ||
| 6. | ALA3993212 | A | Drug metabolism in mouse liver microsomes assessed as oxidation of quinolinone core up to 40 mins in presence of NADPH | Mus musculus | 1 | assay format | Scientific Literature | ||
| 7. | ALA3993213 | A | Drug metabolism in mouse liver microsomes assessed as oxidation of pyrrolidine ring up to 40 mins in presence of NADPH | Mus musculus | 1 | assay format | Scientific Literature | ||
| 8. | ALA3993214 | A | Drug metabolism in mouse liver microsomes assessed as oxidation of benzodioxolane moiety up to 40 mins in presence of NADPH | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3993216 | A | Unbound Cmax in mouse plasma at 50 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4251999 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins by FLIPR assay | Homo sapiens | 170 | cell-based format | Scientific Literature | ||
| 11. | ALA4252000 | A | Apparent permeability in MDCK cells | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA4252001 | A | Efflux ratio of apparent permeability in MDCK cells expressing Pgp | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA4252002 | A | Efflux ratio of apparent permeability in MDCK cells expressing BCRP | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA4252003 | P | Solubility of compound in FaSSIF | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4252004 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 21 | microsome format | Scientific Literature | ||
| 16. | ALA4252017 | B | Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 17. | ALA4252018 | B | Binding affinity to human GlyRalpha3cryst by SPR method | Homo sapiens | 2 | single protein format | Scientific Literature |
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