# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3993207 | Binding | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as compound concentration required to induce up to 3-fold leftward shift in glycine-induced increase in chloride ion flux after 4 mins by Schild plot analysis | Homo sapiens | 35 | ALA3992512 | cell-based format | Scientific Literature | |
2. | ALA3993208 | ADME | Intrinsic clearance in mouse liver microsomes up to 40 mins in presence of NADPH | Mus musculus | 23 | ALA3992512 | assay format | Scientific Literature | |
3. | ALA3993209 | ADME | Passive apparent permeability in MDCK cells | Canis lupus familiaris | 15 | ALA3992512 | cell-based format | Scientific Literature | |
4. | ALA3993210 | ADME | Efflux ratio of passive apparent permeability in MDCK cells harboring human MDR1 | Canis lupus familiaris | 15 | ALA3992512 | cell-based format | Scientific Literature | |
5. | ALA3993211 | ADME | Efflux ratio of passive apparent permeability in MDCK cells harboring human BCRP | Canis lupus familiaris | 14 | ALA3992512 | cell-based format | Scientific Literature | |
6. | ALA3993212 | ADME | Drug metabolism in mouse liver microsomes assessed as oxidation of quinolinone core up to 40 mins in presence of NADPH | Mus musculus | 1 | ALA3992512 | assay format | Scientific Literature | |
7. | ALA3993213 | ADME | Drug metabolism in mouse liver microsomes assessed as oxidation of pyrrolidine ring up to 40 mins in presence of NADPH | Mus musculus | 1 | ALA3992512 | assay format | Scientific Literature | |
8. | ALA3993214 | ADME | Drug metabolism in mouse liver microsomes assessed as oxidation of benzodioxolane moiety up to 40 mins in presence of NADPH | Mus musculus | 1 | ALA3992512 | assay format | Scientific Literature | |
9. | ALA3993216 | ADME | Unbound Cmax in mouse plasma at 50 mg/kg, ip | Mus musculus | 1 | ALA3992512 | organism-based format | Scientific Literature | |
10. | ALA4251999 | Binding | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins by FLIPR assay | Homo sapiens | 170 | ALA4251550 | cell-based format | Scientific Literature | |
11. | ALA4252000 | ADME | Apparent permeability in MDCK cells | Canis lupus familiaris | 6 | ALA4251550 | cell-based format | Scientific Literature | |
12. | ALA4252001 | ADME | Efflux ratio of apparent permeability in MDCK cells expressing Pgp | Canis lupus familiaris | 6 | ALA4251550 | cell-based format | Scientific Literature | |
13. | ALA4252002 | ADME | Efflux ratio of apparent permeability in MDCK cells expressing BCRP | Canis lupus familiaris | 6 | ALA4251550 | cell-based format | Scientific Literature | |
14. | ALA4252003 | Physicochemical | Solubility of compound in FaSSIF | 6 | ALA4251550 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4252004 | ADME | Intrinsic clearance in mouse liver microsomes | Mus musculus | 21 | ALA4251550 | microsome format | Scientific Literature | |
16. | ALA4252017 | Binding | Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assay | Homo sapiens | 2 | ALA4251550 | protein complex format | Scientific Literature | |
17. | ALA4252018 | Binding | Binding affinity to human GlyRalpha3cryst by SPR method | Homo sapiens | 2 | ALA4251550 | single protein format | Scientific Literature |