| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4050581 | B | Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins followed by 4alphaPDD stimulation measured for 5 mins by FLIPR assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 2. | ALA4050583 | B | Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins followed by 4alphaPDD stimulation measured for 5 mins by FLIPR assay | Rattus norvegicus | 11 | cell-based format | Scientific Literature | ||
| 3. | ALA4050584 | B | Antagonist activity at recombinant guinea pig TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins followed by 4alphaPDD stimulation measured for 5 mins by FLIPR assay | Cavia porcellus | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA4050585 | A | Stability in human liver microsomes assessed as parent compound remaining at 0.5 uM in presence of NADPH after 30 mins by LC/MS/MS analysis | Homo sapiens | 24 | assay format | Scientific Literature |
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