# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4017565 | Functional | Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
2. | ALA4017566 | Binding | Inhibition of fatty acid synthase in rat cytosolic hepatic extracts using acetyl CoA and malonyl CoA as substrate preincubated for 30 mins followed by acetyl CoA addition and subsequent incubation for 3 mins prior to malonyl CoA addition measured after 10 mins in presence of NADPH by spectrophotometric method | Rattus norvegicus | 6 | ALA4017443 | assay format | Scientific Literature | |
3. | ALA4017567 | Functional | Antiproliferative activity against human OVCAR3 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
4. | ALA4017568 | Functional | Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
5. | ALA4017569 | Functional | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
6. | ALA4017570 | Functional | Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
7. | ALA4017571 | Functional | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
8. | ALA4017572 | Functional | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay | Homo sapiens | 7 | ALA4017443 | cell-based format | Scientific Literature | |
9. | ALA4017573 | ADME | Antiproliferative activity against fibroblasts (unknown origin) after 72 hrs by MTT assay | Not specified | 7 | ALA4017443 | cell-based format | Scientific Literature | |
10. | ALA4017574 | Binding | Inhibition of fatty acid synthase in human OVCAR3 cells assessed as reduction in fatty acid synthesis at 2 ug/ml pretreated for 2 hrs followed by [U14C]-acetate addition measured after 2 hrs by scintillation counting method relative to control | Homo sapiens | 2 | ALA4017443 | cell-based format | Scientific Literature | |
11. | ALA4017582 | Toxicity | Toxicity in Sprague-Dawley rats assessed as decrease in body weight at 33 mM, icv measured every day for 3 days | Rattus norvegicus | 3 | ALA4017443 | assay format | Scientific Literature | |
12. | ALA4017584 | Toxicity | Toxicity in C57/BL6J mouse assessed as decrease in body weight at 15 mg/kg, ip administered once daily for 3 days measured every day during compound dosing | Mus musculus | 2 | ALA4017443 | organism-based format | Scientific Literature | |
13. | ALA4017585 | Toxicity | Toxicity in C57/BL6J mouse assessed as decrease in food intake at 15 mg/kg, ip administered once daily for 3 days measured every day during compound dosing | Mus musculus | 2 | ALA4017443 | organism-based format | Scientific Literature |