# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4029647 | B | Inhibition of full length recombinant mouse N-terminal GST-tagged PAD2 expressed in baculovirus infected Sf9 cells using benzoyl arginine ethyl ester as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by colorimetric assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
2. | ALA4029648 | B | Inhibition of full length recombinant human N-terminal GST-tagged PAD4 expressed in baculovirus infected Sf9 cells using benzoyl arginine ethylester as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by colorimetric assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
3. | ALA4029649 | B | Inhibition of human PAD1 using BAEE as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by colorimetric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
4. | ALA4029650 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as improvement in physical disability at 100 mg/kg, ip administered once daily for 40 days measured daily during compound dosing | Mus musculus | 3 | organism-based format | Scientific Literature | ||
5. | ALA4029653 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as reduction in accumulation of CD3 positive cells in brain at 100 mg/kg, ip administered once daily for 40 days measured post last dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
6. | ALA4029654 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as reduction in accumulation of MAC3 positive cells in brain at 100 mg/kg, ip administered once daily for 40 days measured post last dose | Mus musculus | 2 | organism-based format | Scientific Literature | ||
7. | ALA4029672 | T | Toxicity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as death at 100 mg/kg, ip administered once daily for 40 days measured during compound dosing (Rvb = 21%) | Mus musculus | 2 | organism-based format | Scientific Literature | ||
8. | ALA4029674 | F | Antiinflammatory activity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as reduction in inflammatory lesions in brain at 100 mg/kg, ip administered once daily for 40 days measured post last dose by hematoxylin and eosin/Luxol-fast blue staining based assay | Mus musculus | 2 | organism-based format | Scientific Literature | ||
9. | ALA4029675 | T | Toxicity in MOG peptide/complete freund's adjuvant/pertussis toxin-induced C57BL/6 mouse autoimmune encephalomyelitis model assessed as change in body weight at 100 mg/kg, ip administered once daily for 40 days measured during compound dosing | Mus musculus | 3 | organism-based format | Scientific Literature |