# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4035279 | Functional | Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
2. | ALA4035280 | Functional | Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
3. | ALA4035281 | Functional | Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 72 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
4. | ALA4035282 | Functional | Antiproliferative activity against human 1205 Lu cells harboring BRAF V600E mutant after 24 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
5. | ALA4035283 | Functional | Antiproliferative activity against human 1205 Lu cells harboring BRAF V600E mutant after 48 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
6. | ALA4035284 | Functional | Antiproliferative activity against human 1205 Lu cells harboring BRAF V600E mutant after 72 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
7. | ALA4035285 | Functional | Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 24 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
8. | ALA4035286 | Functional | Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 48 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
9. | ALA4035287 | Functional | Antiproliferative activity against human A375M cells harboring BRAF V600E mutant after 72 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
10. | ALA4035288 | Functional | Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 24 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
11. | ALA4035289 | Functional | Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 48 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
12. | ALA4035290 | Functional | Antiproliferative activity against human CHL-1 cells harboring wild type BRAF after 72 hrs by MTT assay | Homo sapiens | 8 | ALA4033667 | cell-based format | Scientific Literature | |
13. | ALA4035291 | ADME | Cytotoxicity against human NHDF cells assessed as reduction in cell viability at 2.5 uM after 48 hrs by MTT assay | Homo sapiens | 2 | ALA4033667 | cell-based format | Scientific Literature | |
14. | ALA4035292 | ADME | Cytotoxicity against human NHDF cells assessed as reduction in cell viability at 5 uM after 48 hrs by MTT assay | Homo sapiens | 2 | ALA4033667 | cell-based format | Scientific Literature | |
15. | ALA4035293 | Binding | Inhibition of human DNA topoisomerase 2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA at 0.5 to 5 uM after 1 hr by ethidium bromide staining-based agarose gel electrophoresis | Homo sapiens | 3 | ALA4033667 | single protein format | Scientific Literature | |
16. | ALA4035294 | Binding | Inhibition of DNA topoisomerase 2 in human UACC-903 cells assessed as increase in H2AX phosphorylation at 5 uM after 6 hrs by DAPI staining-based immunocytochemistry analysis | Homo sapiens | 1 | ALA4033667 | cell-based format | Scientific Literature | |
17. | ALA4035295 | Binding | Inhibition of Akt-phosphorylation in human UACC-903 cells after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033667 | cell-based format | Scientific Literature | |
18. | ALA4035296 | Binding | Inhibition of Erk1/2 phosphorylation in human UACC-903 cells at 2.5 to 5 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4033667 | cell-based format | Scientific Literature | |
19. | ALA4035297 | Functional | Induction of apoptosis in human UACC-903 cells assessed as viable cells at 5 uM after 24 hrs by Annexin-V/7-AAD staining-based fluorescence assay (Rvb = 83.90%) | Homo sapiens | 1 | ALA4033667 | cell-based format | Scientific Literature | |
20. | ALA4035298 | Functional | Induction of apoptosis in human UACC-903 cells assessed as early apoptotic cells at 5 uM after 24 hrs by Annexin-V/7-AAD staining-based fluorescence assay (Rvb = 13.15%) | Homo sapiens | 1 | ALA4033667 | cell-based format | Scientific Literature |