# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4004692 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
2. | ALA4004693 | B | Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting method | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
3. | ALA4004694 | B | Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4004695 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as induction of peak current amplitutde at 10 uM at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method relative to acetylcholine | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
5. | ALA4004696 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at 10 uM at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method relative to acetylcholine | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
6. | ALA4004697 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
7. | ALA4004698 | B | Agonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as induction of peak current amplitutde at 10 uM at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method relative to acetylcholine | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4004699 | B | Agonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at 10 uM at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method relative to acetylcholine | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4004700 | B | Agonist activity at human alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4004702 | B | Agonist activity at rat alpha1beta1delta1epsilon nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
11. | ALA4004703 | B | Agonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
12. | ALA4004704 | B | Agonist activity at rat alpha4beta2 nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
13. | ALA4004705 | A | Antagonist activity at human 5-HT3A receptor expressed in HEK293 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA4004706 | B | Activity at human muscarinic M1 receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA4004707 | B | Activity at human muscarinic M3 receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
16. | ALA4004708 | B | Activity at human muscarinic M4 receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA4004709 | B | Activity at human muscarinic M5 receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
18. | ALA4004710 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 3 uM after 10 mins by LC-MS/MS analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
19. | ALA4004711 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 3 uM after 10 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
20. | ALA4004712 | A | Metabolic stability in dog liver microsomes assessed as compound remaining at 3 uM after 10 mins by LC-MS/MS analysis | Canis lupus familiaris | 2 | assay format | Scientific Literature |