# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4022773 | B | Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substrate assessed as decrease in IMP levels after 1 hr by mass spectrometric method | Homo sapiens | 19 | assay format | Scientific Literature | ||
2. | ALA4022774 | B | Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS method | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
3. | ALA4022775 | P | Dissociation constant, pKa of the compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4022776 | P | Lipophilicity, log D of the compound at pH 7 | 2 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA4022777 | P | Equilibrium aqueous solubility of the compound at pH 2 after 20 hrs by HPLC method | 2 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4022778 | P | Equilibrium aqueous solubility of the compound at pH 6 after 20 hrs by HPLC method | 2 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4022779 | P | Equilibrium aqueous solubility of the compound at pH 7.5 after 20 hrs by HPLC method | 3 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4022780 | A | Permeability across apical to basolateral side in MDCK cells at 20 uM | Canis lupus familiaris | 14 | cell-based format | Scientific Literature | ||
9. | ALA4022781 | A | AUC in CD-1 mouse at 10 mg/kg, po by LC-MS/MS method | Mus musculus | 2 | organism-based format | Scientific Literature | ||
10. | ALA4022782 | A | Clearance in CD-1 mouse at 1 mg/kg, iv by LC-MS/MS method | Mus musculus | 2 | organism-based format | Scientific Literature | ||
11. | ALA4022783 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg by LC-MS/MS method | Mus musculus | 3 | organism-based format | Scientific Literature |