| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4031658 | F | Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as tumor growth inhibition at 10 mg/kg, ip qd for 14 days relative to control | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA4031659 | B | Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assay | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 3. | ALA4031660 | B | Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assay | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 4. | ALA4031661 | B | Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by HRE dual-luciferase reporter gene assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4031662 | B | Inhibition of MDH2 in human HCT116 cells assessed as increase in intracellular oxygen content at 10 uM after 6 hrs under hypoxic condition by mono azo rhodamine fluorescent probe based fluorescence method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4031680 | F | Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as tumor growth inhibition at 10 mg/kg, ip qd for 14 days co-treated with (E)-3-[3-(4-adamantan-1-ylphenoxy)acryloylamino]benzoic acid methyl Ester | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4031686 | A | Cytotoxicity against human HCT116 cells harboring HRE-Luc assessed as reduction in cell viability at >40 uM by methylene blue assay | Homo sapiens | 5 | cell-based format | Scientific Literature |
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