# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4058731 | Binding | Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assay | Homo sapiens | 33 | ALA4052817 | single protein format | Scientific Literature | |
2. | ALA4058737 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
3. | ALA4058738 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
4. | ALA4058739 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
5. | ALA4058740 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
6. | ALA4058741 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
7. | ALA4058748 | Binding | Binding affinity to ferrous form of human recombinant IDO-1 | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
8. | ALA4058749 | Binding | Binding affinity to ferric form of human recombinant IDO-1 | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
9. | ALA4058750 | Binding | Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygen | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
10. | ALA4058751 | Binding | Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygen and presence of tryptophan | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
11. | ALA4058752 | Binding | Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS method | Homo sapiens | 3 | ALA4052817 | single protein format | Scientific Literature | |
12. | ALA4058753 | Binding | Inhibition of mouse IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS method | Mus musculus | 2 | ALA4052817 | single protein format | Scientific Literature | |
13. | ALA4058754 | Binding | Inhibition of dog IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS method | Canis lupus familiaris | 2 | ALA4052817 | assay format | Scientific Literature | |
14. | ALA4058755 | Binding | Inhibition of human TDO2 using tryptophan as substrate after 22 mins by LC-MS/MS method | Homo sapiens | 1 | ALA4052817 | single protein format | Scientific Literature | |
15. | ALA4058756 | Binding | Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB method | Homo sapiens | 3 | ALA4052817 | cell-based format | Scientific Literature | |
16. | ALA4058757 | Binding | Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human THP1 cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB method | Homo sapiens | 2 | ALA4052817 | assay format | Scientific Literature | |
17. | ALA4058758 | Binding | Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine production after 24 hrs by LC-MS/MS method | Homo sapiens | 2 | ALA4052817 | single protein format | Scientific Literature | |
18. | ALA4058759 | Binding | Inhibition of human recombinant IDO-2 up to 200 uM using tryptophan as substrate after 22 mins by LC-MS/MS method | Homo sapiens | 1 | ALA4052817 | single protein format | Scientific Literature | |
19. | ALA4058760 | Binding | Inhibition of human ERG up to 300 uM relative to control | Homo sapiens | 1 | ALA4052817 | single protein format | Scientific Literature | |
20. | ALA4058785 | ADME | AUC (infinity) in CD-1 mouse assessed as (R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione at 1 mg/kg, iv by LC-MS/MS method | Mus musculus | 1 | ALA4052817 | organism-based format | Scientific Literature |