#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4020311	B	Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis	Mycobacterium tuberculosis H37Rv	44		assay format	Scientific Literature
2.	ALA4020312	F	Antimicrobial activity against Mycobacterium tuberculosis H37Rv	Mycobacterium tuberculosis	44		assay format	Scientific Literature
3.	ALA4020313	A	Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis	Homo sapiens	8		assay format	Scientific Literature
4.	ALA4020314	T	Selectivity index, ratio of EC50 for inhibition of cytoplasmic LeuRS in HepG2 cells assessed as reduction in protein synthesis to MIC for Mycobacterium tuberculosis H37Rv		8		cell-based format	Scientific Literature
5.	ALA4020315	A	Inhibition of human N-terminal 6His-tagged mitochondrial LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis	Homo sapiens	8		assay format	Scientific Literature
6.	ALA4020316	A	Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine addition measured after 3 hrs by liquid scintillation counting analysis	Homo sapiens	8		cell-based format	Scientific Literature
7.	ALA4020317	A	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	Homo sapiens	8		cell-based format	Scientific Literature
8.	ALA4020352	A	Volume of distribution at steady state in CD-1 mouse at 5 mg/kg, iv after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
9.	ALA4020353	A	Clearance in CD-1 mouse at 5 mg/kg, iv after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
10.	ALA4020354	A	Half life in CD-1 mouse at 5 mg/kg, iv after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
11.	ALA4020355	A	AUC (0 to infinity) in CD-1 mouse at 5 mg/kg, iv after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
12.	ALA4020356	A	Dose normalized AUC (0 to infinity) in CD-1 mouse at 5 mg/kg, iv after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
13.	ALA4020357	A	Cmax in CD-1 mouse at 5 mg/kg administered via oral gavage after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
14.	ALA4020358	A	Tmax in CD-1 mouse at 5 mg/kg administered via oral gavage after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
15.	ALA4020359	A	AUC (0 to 24 hrs) in CD-1 mouse at 5 mg/kg administered via oral gavage by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
16.	ALA4020360	A	Dose normalized AUC (0 to 24 hrs) in CD-1 mouse at 5 mg/kg administered via oral gavage by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
17.	ALA4020361	A	Oral bioavailability in CD-1 mouse at 5 mg/kg administered via gavage after 24 hrs by LC-MS/MS analysis	Mus musculus	1		organism-based format	Scientific Literature
18.	ALA4020362	F	Antimicrobial activity against Mycobacterium tuberculosis H37Rv infected in C57BL/6J mouse assessed as 2 log reduction in bacterial load in lungs administered qd for 8 consecutive days starting on day 1 post infection measured 24 hrs post last dose	Mycobacterium tuberculosis	4		assay format	Scientific Literature