# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3998784 | B | Activation of human CFTR expressed in FRT cells co-expressing YFP assessed as increase in forskolin-stimulated iodide influx measured after 10 mins for 2 to 12 sec by fluorescence assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
2. | ALA3998786 | B | Activation of human CFTR expressed in forskolin-stimulated basolateral membrane permeabilized FRT cells co-expressing YFP assessed as increase in short-circuit current by voltage clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA3998787 | B | Activation of human TMEM16A expressed in FRT cells co-expressing YFP assessed as increase in iodide influx at 10 uM measured after 10 mins for 2 to 12 sec by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA3998788 | B | Inhibition of human TMEM16A expressed in FRT cells co-expressing YFP assessed as decrease in iodide influx at 10 uM measured after 10 mins for 2 to 12 sec in presence of ATP by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA3998789 | F | Increase of iodide influx in human HT-29 cells expressing YFP at 10 uM measured after 10 mins for 2 to 12 sec by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA3998790 | F | Inhibition of iodide influx in human HT-29 cells expressing YFP at 10 uM measured after 10 mins for 2 to 12 sec in presence of ATP by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA3998791 | A | Elevation of cAMP level in Fischer rat thyroid cells co-expressing YFP and human CFTR at 10 uM incubated for 10 mins by immunoassay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
8. | ALA3998792 | A | Elevation of forskolin-stimulated cAMP level in Fischer rat thyroid cells co-expressing YFP and human CFTR at 10 uM incubated for 10 mins by immunoassay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
9. | ALA3998793 | A | Elevation of forskolin/IBMX-stimulated cAMP level in Fischer rat thyroid cells co-expressing YFP and human CFTR at 10 uM incubated for 10 mins by immunoassay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
10. | ALA3998794 | A | Elevation of cytoplasmic calcium level in Fischer rat thyroid cells co-expressing YFP and human CFTR at 10 uM incubated for 5 mins by fluo-4 dye based fluorescence assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
11. | ALA3998795 | A | Suppression of ATP-stimulated elevation of cytoplasmic calcium level in Fischer rat thyroid cells co-expressing YFP and human CFTR at 10 uM incubated for 5 mins by fluo-4 dye based fluorescence assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
12. | ALA3998796 | B | Inhibition of ENaC in human primary bronchial epithelial cells assessed as effect on short-circuit current at 10 uM after 10 mins by voltage clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
13. | ALA3998797 | B | Inhibition of calcium-activated chloride channel in human primary bronchial epithelial cells assessed as inhibition of ATP-induced short-circuit current at 10 uM preincubated for 10 mins followed by ATP addition by voltage clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
14. | ALA3998798 | B | Inhibition of NKCC1 in human primary bronchial epithelial cells assessed as effect on short-circuit current at 10 uM after 10 mins by voltage clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
15. | ALA3998799 | B | Inhibition of potassium channel in human primary bronchial epithelial cells assessed as effect on short-circuit current at 10 uM after 10 mins by voltage clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
16. | ALA3998800 | B | Inhibition of sodium/potassium pump in human primary bronchial epithelial cells assessed as effect on short-circuit current at 10 uM after 10 mins by voltage clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
17. | ALA3998803 | A | Cytotoxicity against Fischer rat thyroid cells assessed as effect on cell survival up to 10 uM after 8 hrs by alamar blue assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
18. | ALA3998804 | P | Solubility of the compound in phosphate buffered solution | 2 | small-molecule physicochemical format | Scientific Literature | |||
19. | ALA3998807 | A | Metabolic stability in rat hepatic microsomes assessed as parent compound remaining at 5 uM after 60 mins in presence of NADPH by LC-MS analysis | Rattus norvegicus | 2 | assay format | Scientific Literature |