# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4012848 | Binding | Activation of HRI in mouse KLN cells transfected with 5'UTR of ATF-4 mRNA fused firefly luciferase mRNA and 5'UTR lacking uORF fused renila luciferase mRNA assessed as increase in eIF2alpha phosphorylation by measuring ratio of firefly luciferase to renila luciferase at 1.25 uM after 16 hrs | Mus musculus | 24 | ALA4011623 | cell-based format | Scientific Literature | |
2. | ALA4012849 | Binding | Activation of HRI in mouse KLN cells transfected with 5'UTR of ATF-4 mRNA fused firefly luciferase mRNA and 5'UTR lacking uORF fused renila luciferase mRNA assessed as increase in eIF2alpha phosphorylation by measuring ratio of firefly luciferase to renila luciferase at 5 uM after 16 hrs | Mus musculus | 24 | ALA4011623 | cell-based format | Scientific Literature | |
3. | ALA4012850 | Functional | Antiproliferative activity against human CRL2813 cells after 5 days by sulforhodamine B assay | Homo sapiens | 24 | ALA4011623 | cell-based format | Scientific Literature | |
4. | ALA4012851 | Binding | Activation of HRI in mouse KLN cells transfected with 5'UTR of ATF-4 mRNA fused firefly luciferase mRNA and 5'UTR lacking uORF fused renila luciferase mRNA assessed as increase in eIF2alpha phosphorylation by measuring ratio of firefly luciferase to renila luciferase after 16 hrs | Mus musculus | 23 | ALA4011623 | cell-based format | Scientific Literature | |
5. | ALA4012852 | Binding | Activation of HRI in human CRL2813 cells assessed as increase in eIF2alpha phosphorylation at 5 uM after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4011623 | cell-based format | Scientific Literature | |
6. | ALA4012853 | Binding | Activation of HRI in human CRL2813 cells assessed as increase in CHOP protein expression at 5 uM after 8 hrs by Western blot analysis | Homo sapiens | 6 | ALA4011623 | cell-based format | Scientific Literature | |
7. | ALA4012854 | Binding | Activation of HRI in human CRL2813 cells assessed as induction of CHOP mRNA level at 5 uM by real-time PCR relative to 18S RNA | Homo sapiens | 6 | ALA4011623 | cell-based format | Scientific Literature | |
8. | ALA4012855 | Binding | Activation of HRI in human CRL2813cells assessed as decrease in cyclin D1 protein expression at 5 uM after 8 hrs by Western blot analysis | Homo sapiens | 6 | ALA4011623 | assay format | Scientific Literature | |
9. | ALA4012856 | ADME | Effect on beta actin protein expression in human CRL2813 cells at 5 uM after 8 hrs by Western blot analysis | Homo sapiens | 6 | ALA4011623 | cell-based format | Scientific Literature |