| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4037806 | A | Half life in human liver microsomes at 10 uM by LC-MS/MS analysis | Homo sapiens | 26 | ALA4033790 | assay format | Scientific Literature | |
| 2. | ALA4037807 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS analysis | Homo sapiens | 26 | ALA4033790 | assay format | Scientific Literature | |
| 3. | ALA4037808 | A | Half life in mouse liver microsomes at 10 uM by LC-MS/MS analysis | Mus musculus | 26 | ALA4033790 | assay format | Scientific Literature | |
| 4. | ALA4037809 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 10 uM after 60 mins by LC-MS analysis | Mus musculus | 26 | ALA4033790 | assay format | Scientific Literature | |
| 5. | ALA4037810 | P | Aqueous solubility of the compound in DI water at pH 7 after 2 hrs by LC-MS analysis | 8 | ALA4033790 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4037811 | P | Solubility of the compound in 0.01M HCl at pH 2 after 2 hrs by LC-MS analysis | 8 | ALA4033790 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4037820 | B | Positive allosteric modulation of GABA-A receptor alpha1beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 GABA induced currents up to 1 uM at -60 mV holding potential by electrophysiological method relative to GABA | Homo sapiens | 3 | ALA4033790 | cell-based format | Scientific Literature | |
| 8. | ALA4037831 | B | Positive allosteric modulation of GABA-A receptor alpha6beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 GABA induced currents at 30 uM at -60 mV holding potential by electrophysiological method relative to GABA | Homo sapiens | 8 | ALA4033790 | cell-based format | Scientific Literature | |
| 9. | ALA4037838 | B | Positive allosteric modulation of GABA-A receptor alpha2beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 GABA induced currents up to 1 uM at -60 mV holding potential by electrophysiological method relative to GABA | Homo sapiens | 3 | ALA4033790 | cell-based format | Scientific Literature | |
| 10. | ALA4037839 | B | Positive allosteric modulation of GABA-A receptor alpha3beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 GABA induced currents up to 1 uM at -60 mV holding potential by electrophysiological method relative to GABA | Homo sapiens | 3 | ALA4033790 | cell-based format | Scientific Literature | |
| 11. | ALA4037840 | B | Positive allosteric modulation of GABA-A receptor alpha4beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 GABA induced currents up to 1 uM at -60 mV holding potential by electrophysiological method relative to GABA | Homo sapiens | 3 | ALA4033790 | cell-based format | Scientific Literature | |
| 12. | ALA4037841 | B | Positive allosteric modulation of GABA-A receptor alpha5beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 GABA induced currents up to 1 uM at -60 mV holding potential by electrophysiological method relative to GABA | Homo sapiens | 3 | ALA4033790 | cell-based format | Scientific Literature | |
| 13. | ALA4037842 | B | Displacement of [3H]-flunitrazepam from rat brain GABA-A receptor benzodiazepine site expressed in HEK293 cell membranes at 10 uM after 60 to 90 mins by scintillation counting | Rattus norvegicus | 10 | ALA4033790 | cell-based format | Scientific Literature | |
| 14. | ALA4037844 | B | Displacement of [3H]-LSD from human recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM after 60 to 90 mins by scintillation counting | Homo sapiens | 4 | ALA4033790 | cell-based format | Scientific Literature | |
| 15. | ALA4037845 | B | Displacement of [3H]-DAMGO from human recombinant MOR expressed in HEK293 cells at 10 uM after 60 to 90 mins by scintillation counting | Homo sapiens | 4 | ALA4033790 | cell-based format | Scientific Literature | |
| 16. | ALA4037846 | B | Displacement of [3H]-SCH233930 from human recombinant dopamine D5 receptor expressed in HEK293 cells at 10 uM after 60 to 90 mins by scintillation counting | Homo sapiens | 1 | ALA4033790 | cell-based format | Scientific Literature | |
| 17. | ALA4037852 | T | Neurotoxicity in Swiss Webster mouse assessed as induction of motor impairment at 40 mg/kg administered via oral gavage measured after 10 to 60 mins by rotarod method | Mus musculus | 18 | ALA4033790 | organism-based format | Scientific Literature | |
| 18. | ALA4037854 | A | Cmax in Wistar rat plasma at 10 mg/kg, ip administered as single dose measured at 5 to 720 mins post dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | ALA4033790 | organism-based format | Scientific Literature | |
| 19. | ALA4037855 | A | Tmax in Wistar rat plasma at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | ALA4033790 | organism-based format | Scientific Literature | |
| 20. | ALA4037856 | A | AUC (0 to 12 hrs) in Wistar rat plasma at 10 mg/kg, ip administered as single dose by HPLC-MS/MS analysis | Rattus norvegicus | 6 | ALA4033790 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!