# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4015695 | B | Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechst 33342 addition measured immediately at 60 sec time interval for 120 mins by fluorescence assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
2. | ALA4015696 | B | Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux at 10 mM preincubated for 30 mins followed by Hoechst 33342 addition measured immediately at 60 sec time interval for 120 mins by fluorescence assay relative to Ko143 | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
3. | ALA4048749 | B | Activation of recombinant human ABCG2 ATPase activity expressed in baculovirus infected High five insect cell membranes after 20 mins by ascorbic acid ammonia molybdate reaction-based colorimetric method | Homo sapiens | 35 | assay format | Scientific Literature | ||
4. | ALA4048750 | B | Activation of recombinant human ABCG2 ATPase activity expressed in baculovirus infected High five insect cell membranes after 20 mins by ascorbic acid ammonia molybdate reaction-based colorimetric method relative to control | Homo sapiens | 35 | assay format | Scientific Literature | ||
5. | ALA4425525 | B | Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Hoechst 33342 addition by Hoechst 33342 accumulation assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
6. | ALA4425526 | B | Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Pheophorbide A addition by Pheophorbide A assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
7. | ALA4425531 | A | Intrinsic cytotoxicity against MDCK2 cells over-expressing human ABCG2 incubated for 72 hrs by MTT assay | Canis lupus familiaris | 12 | cell-based format | Scientific Literature | ||
8. | ALA4425532 | A | Intrinsic cytotoxicity against parental MDCK2 cells incubated for 72 hrs by MTT assay | Canis lupus familiaris | 12 | cell-based format | Scientific Literature | ||
9. | ALA4425533 | T | Therapeutic index, ratio of GI50 for intrinsic cytotoxicity against MDCK2 cells over-expressing human ABCG2 top IC50 for inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells | 12 | cell-based format | Scientific Literature | |||
10. | ALA4425535 | B | Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells assessed as enhancement of SN-38-induced cytotoxicity incubated for 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4425536 | B | Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells assessed as enhancement of Hoechst 33342-induced cytotoxicity incubated for 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4425537 | B | Inhibition of BCRP (unknown origin) expressed in MDCK2 cells assessed as enhancement of mitoxantrone-induced cytotoxicity incubated for 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA5245773 | B | Inhibition of ABCG2 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature |