| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4012040 | Toxicity | Toxicity in Balb-C mouse assessed as behavior changes at 0.1 to 1 mg/kg, ip measured after 48 hrs | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 2. | ALA4012041 | Functional | Anti-depressant like activity in wild-type Balb-C mouse assessed as reduction in duration of immobility at 1 mg/kg, ip administered 15 to 30 mins prior to the testing measured on day 3 post dose by force swim test | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 3. | ALA4012042 | Binding | Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake measured every 30 secs for 1 hr by fluorescence assay | Homo sapiens | 28 | ALA4011591 | cell-based format | Scientific Literature | |
| 4. | ALA4012043 | Binding | Antagonist activity at P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP addition measured after 30 mins by ELISA | Homo sapiens | 7 | ALA4011591 | assay format | Scientific Literature | |
| 5. | ALA4012044 | Binding | Ratio of IC50 for P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake to IC50 for P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release | Homo sapiens | 7 | ALA4011591 | cell-based format | Scientific Literature | |
| 6. | ALA4012045 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 5.8 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 7. | ALA4012046 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 6 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 8. | ALA4012047 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 2.5 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 9. | ALA4012048 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 2.2 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 10. | ALA4012049 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 10 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 11. | ALA4012050 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 10.1 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 12. | ALA4012051 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 15 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 13. | ALA4012052 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 23 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 14. | ALA4012053 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 37 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 15. | ALA4012054 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 39 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 16. | ALA4012055 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 58 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 17. | ALA4012056 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 63 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 18. | ALA4012057 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 76 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 19. | ALA4012058 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 92 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature | |
| 20. | ALA4012059 | ADME | Plasma concentration in Balb-C mouse at 2 mg/kg, iv administered as bolus dose measured after 120 mins by LC-MS analysis | Mus musculus | 1 | ALA4011591 | organism-based format | Scientific Literature |
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