| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4047811 | Functional | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured after 1.7 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 17 | ALA4043265 | cell-based format | Scientific Literature | |
| 2. | ALA4047824 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate pretreated for 15 mins followed by NADPH addition measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4043265 | assay format | Scientific Literature | |
| 3. | ALA4047825 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate pretreated for 15 mins followed by NADPH addition measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4043265 | assay format | Scientific Literature | |
| 4. | ALA4047826 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate pretreated for 15 mins followed by NADPH addition measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4043265 | assay format | Scientific Literature | |
| 5. | ALA4047827 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate pretreated for 15 mins followed by NADPH addition measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4043265 | assay format | Scientific Literature | |
| 6. | ALA4047828 | Functional | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate induced-calcium mobilization at 30 uM preincubated for 2.3 mins followed by glutamate addition measured after 1.7 mins by Fluo-4 AM dye based fluorescence assay relative to glutamate | Rattus norvegicus | 17 | ALA4043265 | cell-based format | Scientific Literature | |
| 7. | ALA4047829 | ADME | Fraction unbound in rat plasma at 5 uM after 4 hrs by equilibrium dialysis method | Rattus norvegicus | 12 | ALA4043265 | cell-free format | Scientific Literature | |
| 8. | ALA4047830 | ADME | Fraction unbound in human plasma at 5 uM after 4 hrs by equilibrium dialysis method | Homo sapiens | 12 | ALA4043265 | cell-free format | Scientific Literature |
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