# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4017326 | B | Inhibition of C-terminal His-tagged HCV genotype 1b NS5Bdelta21 expressed in Escherichia coli BL21 (DE3) using synthetic 20mer RNA/[32P]GpG as template/primer after 90 mins by PAGE analysis | Hepatitis C virus subtype 1b | 1 | ALA4014354 | assay format | Scientific Literature | |
2. | ALA4017327 | B | Inhibition of HCV genotype 1b NS5B S96T mutant | Hepatitis C virus subtype 1b | 1 | ALA4014354 | assay format | Scientific Literature | |
3. | ALA4017328 | B | Inhibition of wild type HCV genotype 2a NS5B | Hepatitis C virus subtype 2a | 1 | ALA4014354 | assay format | Scientific Literature | |
4. | ALA4017330 | B | Inhibition of wild type HCV genotype 4a NS5B | Hepatitis C virus subtype 4a | 1 | ALA4014354 | assay format | Scientific Literature | |
5. | ALA4017331 | B | Selectivity ratio of IC50 for HCV genotype 1b NS5B S96T mutant to IC50 for C-terminal His-tagged HCV genotype 1b NS5Bdelta21 | Hepatitis C virus subtype 1b | 1 | ALA4014354 | assay format | Scientific Literature | |
6. | ALA4017332 | B | Selectivity ratio of IC50 for wild type HCV genotype 2a NS5B to IC50 for C-terminal His-tagged HCV genotype 1b NS5Bdelta21 | 1 | ALA4014354 | assay format | Scientific Literature | ||
7. | ALA4017333 | B | Selectivity ratio of IC50 for wild type HCV genotype 4a NS5B to IC50 for C-terminal His-tagged HCV genotype 1b NS5Bdelta21 | 1 | ALA4014354 | assay format | Scientific Literature | ||
8. | ALA4017349 | B | Inhibition of RNA polymerase 2 isolated from human HeLa cell nuclear extract assessed as decrease in incorporation of P32-alpha-CTP after 2 hrs by scintillation counting method | Homo sapiens | 3 | ALA4014354 | cell-based format | Scientific Literature | |
9. | ALA4017350 | B | Inhibition of human POLRMT using 5'-P32-RNA/DNA hybrid assessed as incorporation of UTP at 100 uM after 2 hrs by scintillation counting method relative to control | Homo sapiens | 2 | ALA4014354 | single protein format | Scientific Literature | |
10. | ALA4017351 | B | Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysis | Homo sapiens | 3 | ALA4014354 | single protein format | Scientific Literature | |
11. | ALA4017352 | B | Inhibition of human DNA polymerase beta using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysis | Homo sapiens | 3 | ALA4014354 | single protein format | Scientific Literature | |
12. | ALA4017353 | B | Inhibition of human DNA polymerase gamma using 5' end radiolabeled 24nt DNA/36nt DNA as primer/template after 120 mins by PAGE analysis | Homo sapiens | 3 | ALA4014354 | assay format | Scientific Literature | |
13. | ALA4394392 | B | Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template measured after 2 hrs by microscintillation counting method | Hepatitis C virus | 13 | ALA4393666 | single protein format | Scientific Literature | |
14. | ALA4394394 | A | Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control | Homo sapiens | 8 | ALA4393666 | single protein format | Scientific Literature | |
15. | ALA4394396 | A | Inhibition of human DNA polymerase-beta assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control | Homo sapiens | 8 | ALA4393666 | single protein format | Scientific Literature | |
16. | ALA4394397 | A | Inhibition of human DNA polymerase-gamma assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control | Homo sapiens | 8 | ALA4393666 | single protein format | Scientific Literature | |
17. | ALA4394398 | A | Inhibition of RNA polymerase 2 in human HeLa cell nuclear extract assessed as reduction in RNA transcription by PAGE analysis | Homo sapiens | 8 | ALA4393666 | cell-based format | Scientific Literature |