# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4038389 | ADME | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 4 | ALA4038268 | organism-based format | Scientific Literature | |
2. | ALA4038392 | Binding | Binding affinity to His-tagged BRD4 BD1-BD2 (K57 to K550 residues) (unknown origin) after 1 hr by Alexa-647-conjugated probe based TR-FRET assay | Homo sapiens | 40 | ALA4038268 | single protein format | Scientific Literature | |
3. | ALA4038393 | Functional | Antiproliferative activity against human MX1 cells incubated over 72 hrs by Cell Titre Glo luminescence assay | Homo sapiens | 36 | ALA4038268 | cell-based format | Scientific Literature | |
4. | ALA4038394 | Binding | Inhibition of BRD4 (unknown origin) expressed in human H1299 cells co-expressing HPV16-LCR/E2 after 24 hrs by Bright Glo-luciferase reporter gene assay | Homo sapiens | 36 | ALA4038268 | cell-based format | Scientific Literature | |
5. | ALA4038395 | ADME | Unbound clearance in mouse plasma at 3 mg/kg, iv | Mus musculus | 4 | ALA4038268 | organism-based format | Scientific Literature | |
6. | ALA4038396 | ADME | Unbound AUC in mouse at 10 mg/kg, po | Mus musculus | 4 | ALA4038268 | organism-based format | Scientific Literature | |
7. | ALA4038397 | ADME | Half life in mouse at 3 mg/kg, iv | Mus musculus | 4 | ALA4038268 | organism-based format | Scientific Literature | |
8. | ALA4038399 | Functional | Antitumor activity against human OPM2 cells xenografted in SCID-Beige mouse assessed as tumor growth inhibition at 30 mg/kg, po qd for 21 days measured twice per week during compound dosing relative to control | Homo sapiens | 1 | ALA4038268 | organism-based format | Scientific Literature | |
9. | ALA4038401 | ADME | Unbound intrinsic clearance in mouse liver microsomes | Mus musculus | 26 | ALA4038268 | assay format | Scientific Literature | |
10. | ALA4038402 | Physicochemical | Permeability of the compound | 23 | ALA4038268 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4038403 | Binding | Inhibition of human BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
12. | ALA4038404 | Binding | Inhibition of human BRD9 isoform 1 (R130 to V259 residues) expressed in bacterial expression system at 1 uM by BROMOscan assay relative to control | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
13. | ALA4038405 | Binding | Inhibition of human CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
14. | ALA4038406 | Binding | Inhibition of human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
15. | ALA4038407 | Binding | Inhibition of human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
16. | ALA4038409 | Binding | Inhibition of human SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
17. | ALA4038410 | Binding | Inhibition of human TRIM24-phd-bromo (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 3 | ALA4038268 | assay format | Scientific Literature | |
18. | ALA4038411 | Binding | Inhibition of human TAF1L (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 2 | ALA4038268 | assay format | Scientific Literature | |
19. | ALA4038414 | Binding | Inhibition of human BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay | Homo sapiens | 3 | ALA4038268 | assay format | Scientific Literature | |
20. | ALA4038416 | Binding | Inhibition of human BRPF1 (E627 to G740 residues) expressed in bacterial expression system at 1 uM by BROMOscan assay | Homo sapiens | 3 | ALA4038268 | assay format | Scientific Literature |