# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4000295 | Functional | Inhibition of luciferase expression in human HT1080 cells after 24 hrs | Homo sapiens | 1 | ALA4000145 | cell-based format | Scientific Literature | |
2. | ALA4000296 | Binding | Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-catenin-mediated transcriptional activity after 24 hrs by Steady-Glo luciferase assay | Homo sapiens | 16 | ALA4000145 | cell-based format | Scientific Literature | |
3. | ALA4000299 | Physicochemical | Thermodynamic solubility of the compound at pH 7.4 | 4 | ALA4000145 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4000300 | Physicochemical | Permeability of the compound at pH 7.4 by PAMPA assay | 4 | ALA4000145 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4000301 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 9 | ALA4000145 | single protein format | Scientific Literature | |
6. | ALA4000302 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 9 | ALA4000145 | single protein format | Scientific Literature | |
7. | ALA4000304 | ADME | Intrinsic clearance in mouse liver microsomes | Mus musculus | 11 | ALA4000145 | assay format | Scientific Literature | |
8. | ALA4000305 | Binding | Inhibition of PORCN-mediated V5-tagged Wnt3A palmitoylation in human HeLa cells at 100 nM measured after over night incubation by Western blot analysis | Homo sapiens | 3 | ALA4000145 | cell-based format | Scientific Literature | |
9. | ALA4000306 | Binding | Inhibition of mouse PORCN expressed in human HT1080 cells coexpressing Wnt/beta-catenin assessed as decrease in beta-catenin-mediated transcriptional activity at 0.2 to 625 nM after 24 hrs in presence of Wnt3a by luciferase reporter gene assay | Mus musculus | 1 | ALA4000145 | cell-based format | Scientific Literature | |
10. | ALA4000307 | Functional | Antitumor activity in Balb/c mouse MMTV-Wnt1 model assessed as tumor growth inhibition at 1 mg/kg administered once daily for 14 days via oral gavage relative to vehicle treated control | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
11. | ALA4000308 | Functional | Antitumor activity in Balb/c mouse MMTV-Wnt1 model assessed as tumor growth inhibition at 3 mg/kg administered once daily for 14 days via oral gavage relative to vehicle treated control | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
12. | ALA4000309 | Functional | Antitumor activity in Balb/c mouse MMTV-Wnt1 model assessed as tumor growth inhibition at 10 mg/kg administered once daily for 14 days via oral gavage relative to vehicle treated control | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
13. | ALA4000310 | Functional | Antitumor activity in Balb/c mouse MMTV-Wnt1 model assessed as tumor growth inhibition administered once daily for 14 days via oral gavage | Mus musculus | 1 | ALA4000145 | assay format | Scientific Literature | |
14. | ALA4000311 | ADME | Oral bioavailability in mouse at 5 mg/kg | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
15. | ALA4000312 | ADME | Cmax in mouse at 5 mg/kg, po | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
16. | ALA4000313 | ADME | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
17. | ALA4000314 | ADME | AUC (0 to last) in mouse at 5 mg/kg, po | Mus musculus | 1 | ALA4000145 | organism-based format | Scientific Literature | |
18. | ALA5227328 | Binding | Inhibition of mouse STF3A | Mus musculus | 5 | ALA5226302 | single protein format | Scientific Literature | |
19. | ALA5227329 | Physicochemical | Solubility of the compound at pH 7.4 | 4 | ALA5226302 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA5227331 | ADME | Oral bioavailability in mouse at 2.5 mg/kg | Mus musculus | 3 | ALA5226302 | organism-based format | Scientific Literature |