| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4015218 | F | Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation at 10 uM after 15 mins in presence of [3H]-cAMP by radiometric assay relative to decanoic acid | Homo sapiens | 61 | ALA4014307 | cell-based format | Scientific Literature | |
| 2. | ALA4015219 | F | Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in presence of [3H]-cAMP by radiometric assay | Homo sapiens | 63 | ALA4014307 | cell-based format | Scientific Literature | |
| 3. | ALA4015220 | B | Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assay | Homo sapiens | 63 | ALA4014307 | cell-based format | Scientific Literature | |
| 4. | ALA4015221 | B | Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase complementation assay relative to embelin | Homo sapiens | 36 | ALA4014307 | cell-based format | Scientific Literature | |
| 5. | ALA4015224 | A | Effect on forskolin-induced cAMP accumulation in CHO cells preincubated for 5 mins followed by forskolin addition measured after 15 mins in presence of [3H]-cAMP by radiometric assay | Cricetulus griseus | 3 | ALA4014307 | cell-based format | Scientific Literature | |
| 6. | ALA4015226 | F | Ratio of EC50 for human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment to EC50 for Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation | Homo sapiens | 3 | ALA4014307 | cell-based format | Scientific Literature | |
| 7. | ALA4015228 | F | Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.1 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM) | Homo sapiens | 2 | ALA4014307 | cell-based format | Scientific Literature | |
| 8. | ALA4015229 | F | Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.3 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM) | Homo sapiens | 2 | ALA4014307 | cell-based format | Scientific Literature | |
| 9. | ALA4015232 | F | Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.01 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM) | Homo sapiens | 1 | ALA4014307 | cell-based format | Scientific Literature | |
| 10. | ALA4015233 | F | Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid EC50 at 0.03 uM after 15 mins in presence of [3H]-cAMP by radiometric assay (Rvb = 9.22 to 13.1 uM) | Homo sapiens | 1 | ALA4014307 | cell-based format | Scientific Literature | |
| 11. | ALA4015234 | F | Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forskolin-induced cAMP accumulation by measuring decanoic acid Kb after 15 mins in presence of [3H]-cAMP by radiometric assay | Homo sapiens | 2 | ALA4014307 | cell-based format | Scientific Literature | |
| 12. | ALA4015236 | F | Agonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells assessed as induction of intracellular calcium level at 10 uM measured at 1.2 secs time interval by Fluo-4-AM dye based fluorescence assay | Homo sapiens | 60 | ALA4014307 | cell-based format | Scientific Literature | |
| 13. | ALA4015237 | B | Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment at 10 uM after 90 mins by beta-galactosidase complementation assay | Homo sapiens | 61 | ALA4014307 | cell-based format | Scientific Literature | |
| 14. | ALA4015239 | B | Antagonist activity at human FFAR4 expressed in CHO cells assessed as inhibition of TUG-89-induced beta-arrestin recruitment at 10 uM preincubated for 30 mins followed by TUG-89 addition measured after 90 mins by beta-galactosidase complementation assay | Homo sapiens | 61 | ALA4014307 | cell-based format | Scientific Literature | |
| 15. | ALA4015240 | B | Agonist activity at human GPR35 at 10 uM | Homo sapiens | 4 | ALA4014307 | single protein format | Scientific Literature | |
| 16. | ALA4015244 | A | Activation of AhR in human HepG2 cells assessed as induction of CYP1A1 mRNA expression at 5 to 20 uM after 18 hrs by RT-PCR method | Homo sapiens | 1 | ALA4014307 | cell-based format | Scientific Literature | |
| 17. | ALA4343781 | B | Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method relative to control | Homo sapiens | 16 | ALA4342430 | cell-based format | Scientific Literature | |
| 18. | ALA4343782 | B | Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PSB-1584 binding measured after 6 hrs by scintillation counting method | Homo sapiens | 16 | ALA4342430 | cell-based format | Scientific Literature | |
| 19. | ALA4675996 | B | Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (unknown origin) expressed in T-REx-293 cells co-expressing Galphai2 incubated for 1 hr by liquid scintillation counting analysis | Homo sapiens | 3 | ALA4673243 | cell-based format | Scientific Literature | |
| 20. | ALA4712173 | F | Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid scintillation spectroscopy | Homo sapiens | 2 | ALA4706630 | cell membrane format | Scientific Literature |
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